Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 62173..62780 | Replicon | plasmid pUK040_1 |
| Accession | NZ_CP091578 | ||
| Organism | Enterococcus faecium strain UK040 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | E3USU0 |
| Locus tag | L5466_RS13520 | Protein ID | WP_002321032.1 |
| Coordinates | 62430..62780 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | A0A829F3C0 |
| Locus tag | L5466_RS13515 | Protein ID | WP_002287514.1 |
| Coordinates | 62173..62436 (+) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5466_RS13470 (L5466_13470) | 57209..58108 | + | 900 | WP_002322787.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| L5466_RS13475 (L5466_13475) | 58111..58596 | + | 486 | WP_002296241.1 | single-stranded DNA-binding protein | - |
| L5466_RS13480 (L5466_13480) | 58962..59222 | + | 261 | WP_002296240.1 | hypothetical protein | - |
| L5466_RS13485 (L5466_13485) | 59663..59869 | + | 207 | WP_002296239.1 | hypothetical protein | - |
| L5466_RS13490 (L5466_13490) | 59869..60120 | + | 252 | WP_002296238.1 | hypothetical protein | - |
| L5466_RS13495 (L5466_13495) | 60135..60572 | + | 438 | WP_002296237.1 | hypothetical protein | - |
| L5466_RS13500 (L5466_13500) | 60565..61272 | + | 708 | WP_002353391.1 | hypothetical protein | - |
| L5466_RS13505 (L5466_13505) | 61437..61637 | + | 201 | WP_002330566.1 | hypothetical protein | - |
| L5466_RS13510 (L5466_13510) | 61653..61832 | + | 180 | WP_002305761.1 | hypothetical protein | - |
| L5466_RS13515 (L5466_13515) | 62173..62436 | + | 264 | WP_002287514.1 | hypothetical protein | Antitoxin |
| L5466_RS13520 (L5466_13520) | 62430..62780 | + | 351 | WP_002321032.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| L5466_RS13525 (L5466_13525) | 62804..63418 | - | 615 | WP_010729795.1 | recombinase family protein | - |
| L5466_RS13530 (L5466_13530) | 63732..64154 | + | 423 | WP_002288787.1 | hypothetical protein | - |
| L5466_RS13535 (L5466_13535) | 64164..64505 | + | 342 | WP_014401516.1 | hypothetical protein | - |
| L5466_RS13540 (L5466_13540) | 64577..65161 | + | 585 | WP_002299575.1 | recombinase family protein | - |
| L5466_RS13545 (L5466_13545) | 65350..66030 | - | 681 | WP_010861579.1 | IS6-like element IS1216 family transposase | - |
| L5466_RS13550 (L5466_13550) | 66084..66794 | - | 711 | WP_010729797.1 | GntR family transcriptional regulator | - |
| L5466_RS13555 (L5466_13555) | 66778..67512 | - | 735 | WP_010729798.1 | GntR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..231428 | 231428 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13255.28 Da Isoelectric Point: 8.0280
>T233892 WP_002321032.1 NZ_CP091578:62430-62780 [Enterococcus faecium]
MVRKPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVTVAPISSTTRNYPLYVNINSEYEMKTTGKVLLDQLT
TIDYEARECIFLEKAHDSLVEELLMKVRTVFQKVSK
MVRKPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVTVAPISSTTRNYPLYVNINSEYEMKTTGKVLLDQLT
TIDYEARECIFLEKAHDSLVEELLMKVRTVFQKVSK
Download Length: 351 bp
>T233892 NZ_LN847353:c1073245-1072991 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10183.60 Da Isoelectric Point: 4.6865
>AT233892 WP_002287514.1 NZ_CP091578:62173-62436 [Enterococcus faecium]
MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKIIQEEVNGQKRLIIEAANIENELTIEQLFENYTDERNHVTIQNLGE
AVGNEKW
MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKIIQEEVNGQKRLIIEAANIENELTIEQLFENYTDERNHVTIQNLGE
AVGNEKW
Download Length: 264 bp
>AT233892 NZ_LN847353:c1073489-1073247 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829F5H8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829F3C0 |