233888

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 8390..8883 Replicon 2 plasmid p2-mcr
Accession NZ_CP091575
Organism Salmonella enterica strain

Toxin (Protein)


Gene name TsxA Uniprot ID U9Y9W8
Locus tag INN74_RS26185 Protein ID WP_001230709.1
Coordinates 8390..8644 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID U9Y4R8
Locus tag INN74_RS26190 Protein ID WP_000151456.1
Coordinates 8641..8883 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN74_RS26145 (INN74_26145) 3905..4057 + 153 Protein_2 DUF5431 family protein -
INN74_RS26150 (INN74_26150) 4002..4124 + 123 WP_223685802.1 Hok/Gef family protein -
INN74_RS26155 (INN74_26155) 4274..4870 + 597 WP_000125165.1 ProQ/FINO family protein -
INN74_RS26160 (INN74_26160) 4888..5172 - 285 WP_001162371.1 hypothetical protein -
INN74_RS26165 (INN74_26165) 5246..5911 - 666 WP_000532149.1 division plane positioning ATPase MipZ -
INN74_RS26170 (INN74_26170) 6499..6828 + 330 WP_000855119.1 hypothetical protein -
INN74_RS26175 (INN74_26175) 7232..7747 + 516 WP_001025393.1 J domain-containing protein -
INN74_RS26180 (INN74_26180) 7851..8393 + 543 WP_001083904.1 hypothetical protein -
INN74_RS26185 (INN74_26185) 8390..8644 + 255 WP_001230709.1 hypothetical protein Toxin
INN74_RS26190 (INN74_26190) 8641..8883 + 243 WP_000151456.1 hypothetical protein Antitoxin
INN74_RS26195 (INN74_26195) 9454..9747 + 294 WP_000673428.1 hypothetical protein -
INN74_RS26200 (INN74_26200) 10164..10607 - 444 WP_000192625.1 hypothetical protein -
INN74_RS26205 (INN74_26205) 10904..11086 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
INN74_RS26210 (INN74_26210) 11111..11548 + 438 WP_000466318.1 type II toxin-antitoxin system HicB family antitoxin -
INN74_RS26215 (INN74_26215) 11679..12119 - 441 WP_052993860.1 hypothetical protein -
INN74_RS26220 (INN74_26220) 12139..12738 - 600 WP_021500050.1 hypothetical protein -
INN74_RS26225 (INN74_26225) 12785..13486 - 702 WP_000280995.1 StbB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mcr-1.1 - 1..65271 65271
- flank IS/Tn - - 2296..3444 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Cro/C1-type helix-turn-helix domain

(48-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9942.47 Da        Isoelectric Point: 10.1206

>T233888 WP_001230709.1 NZ_CP091575:8390-8644 [Salmonella enterica]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA

Download         Length: 255 bp

>T233888 NZ_LN847264:326657-326962 [Pseudomonas sp. CCOS 191]
ATGGCAGACCTCAAACTTACCAAGTGGGACGCGGCCGATCACTTGAAGACCGAGCAAGACGTTGTCCTCTACCTGGAGGC
GTGTCTTGAGGAAAATGATCCAGTGCTGCTTGCTGCCGCATTGGGAGACATAGCGCGTGCCCGTGGAATGGCTCAGCTGG
CTCGTGATACCGGCTTGACCCGGGAGGGGCTATACAAGGCGCTGTCTGCGGAGGGGAACCCTAGCCTTGCGACCATCATG
AAGGTAATGGCAGCCCTTGGCGTGAGGTTGCATGCCGGGGCAGTGCCTCCTCAGGTAGCGGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9136.45 Da        Isoelectric Point: 7.2775

>AT233888 WP_000151456.1 NZ_CP091575:8641-8883 [Salmonella enterica]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP

Download         Length: 243 bp

>AT233888 NZ_LN847264:326357-326647 [Pseudomonas sp. CCOS 191]
ATGCACACGCTCATACAGACCGACAGATACAAGAAGTGGTTTGCTGCCTTGCGGGATGCTCGCGCTCAGGCCCGCATCAA
CGTGCGGCTGCGGCGGGTCGAGCTTGGCGTGCTGGGGGATTGCAAGCCAGTGGGCGAGGGTGTTCTGGAGCTGAGAGTCG
ACTACGGGCCTGGCTATCGAGTCTATCTGGCCCGGCGCGGCTATGAGGTGATACTTCTCCTTGCCGGGGGAGACAAAACC
ACTCAAGCCCGCGACATCAAATCTGCACTCAAGCTGGCGCGTGATATCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9H8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3G9GNF5

References