Detailed information of TA system TA233879

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 83870..85493
• Replicon: 2 plasmid p2-2
• Accession: NZ_CP091572
• Organism: Salmonella enterica strain

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: H9TH67
• Locus tag: INN74_RS24710
• Protein ID: WP_000088046.1
• Coordinates: 83870..85195 (-)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A5Z6V2D1
• Locus tag: INN74_RS24715
• Protein ID: WP_024136327.1
• Coordinates: 85200..85493 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN74_RS24680 (INN74_24680)	80540..80839	-	300	WP_001572440.1	hypothetical protein	-
INN74_RS24685 (INN74_24685)	80894..81130	-	237	Protein_94	type I restriction-modification system subunit M N-terminal domain-containing protein	-
INN74_RS24690 (INN74_24690)	81584..82009	-	426	WP_001043843.1	hypothetical protein	-
INN74_RS24695 (INN74_24695)	82263..83078	-	816	WP_001572439.1	HNH endonuclease signature motif containing protein	-
INN74_RS24700 (INN74_24700)	83091..83501	-	411	WP_000985911.1	hypothetical protein	-
INN74_RS24705 (INN74_24705)	83603..83809	-	207	WP_000134171.1	hypothetical protein	-
INN74_RS24710 (INN74_24710)	83870..85195	-	1326	WP_000088046.1	type II toxin-antitoxin system HipA family toxin	Toxin
INN74_RS24715 (INN74_24715)	85200..85493	-	294	WP_024136327.1	helix-turn-helix transcriptional regulator	Antitoxin
INN74_RS24720 (INN74_24720)	86097..86489	-	393	WP_000341066.1	hypothetical protein	-
INN74_RS24725 (INN74_24725)	86862..87203	+	342	WP_001151575.1	hypothetical protein	-
INN74_RS24730 (INN74_24730)	87295..87486	+	192	WP_000398480.1	hypothetical protein	-
INN74_RS24735 (INN74_24735)	87536..87817	+	282	WP_000077926.1	hypothetical protein	-
INN74_RS26570	88158..88289	-	132	WP_000374059.1	hypothetical protein	-
INN74_RS24740 (INN74_24740)	88380..89621	-	1242	WP_001053338.1	VWA domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	cmlA1 / ant(3'')-Ia / sul3 / aph(3')-Ia / aac(3)-IVa / aph(4)-Ia / sul2 / floR / oqxB / oqxA / sul1 / dfrA12 / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE	-	1..180977	180977

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (9-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (21-69)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 50249.20 Da
• Isoelectric Point: 6.1927

>T233879 WP_000088046.1 NZ_CP091572:c85195-83870 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Nucleotide

• Length: 1326 bp

>T233879 NZ_LN832404:c3696600-3696493 [Escherichia coli K-12]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10946.35 Da
• Isoelectric Point: 10.0925

>AT233879 WP_024136327.1 NZ_CP091572:c85493-85200 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Nucleotide

• Length: 294 bp

>AT233879 NZ_LN832404:3696648-3696714 [Escherichia coli K-12]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A3T0VBU1

Antitoxin

• AlphaFold DB: A0A5Z6V2D1