Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4449776..4450557 Replicon chromosome
Accession NZ_CP091571
Organism Salmonella enterica strain

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag INN74_RS21815 Protein ID WP_000626099.1
Coordinates 4449776..4450267 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag INN74_RS21820 Protein ID WP_001110452.1
Coordinates 4450264..4450557 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN74_RS21775 (4444962) 4444962..4445204 - 243 WP_197603740.1 hypothetical protein -
INN74_RS21780 (4445201) 4445201..4445557 - 357 WP_033567083.1 hypothetical protein -
INN74_RS21785 (4445554) 4445554..4446426 - 873 WP_033567082.1 ParA family protein -
INN74_RS21790 (4446617) 4446617..4446694 - 78 Protein_4269 helix-turn-helix domain-containing protein -
INN74_RS21795 (4446785) 4446785..4447117 - 333 WP_001165471.1 MerR family transcriptional regulator -
INN74_RS21800 (4447189) 4447189..4447566 + 378 WP_000916345.1 EthD family reductase -
INN74_RS21805 (4448599) 4448599..4448673 + 75 Protein_4272 porin family protein -
INN74_RS21810 (4448776) 4448776..4449528 + 753 WP_000842434.1 non-specific acid phosphatase -
INN74_RS21815 (4449776) 4449776..4450267 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
INN74_RS21820 (4450264) 4450264..4450557 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
INN74_RS21825 (4450874) 4450874..4451095 + 222 WP_001576552.1 hypothetical protein -
INN74_RS21830 (4451360) 4451360..4452235 + 876 WP_000921674.1 AraC family transcriptional regulator -
INN74_RS21835 (4452232) 4452232..4452519 + 288 WP_001269916.1 transcriptional regulator RtsB -
INN74_RS21840 (4452542) 4452542..4452757 + 216 WP_001595136.1 hypothetical protein -
INN74_RS21845 (4452765) 4452765..4453034 + 270 WP_010989096.1 hypothetical protein -
INN74_RS21850 (4453328) 4453328..4454233 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T233876 WP_000626099.1 NZ_CP091571:c4450267-4449776 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T233876 NZ_LN832404:c3165057-3164761 [Escherichia coli K-12]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT233876 WP_001110452.1 NZ_CP091571:c4450557-4450264 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT233876 NZ_LN832404:c3164759-3164364 [Escherichia coli K-12]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References