Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4239698..4240214 Replicon chromosome
Accession NZ_CP091571
Organism Salmonella enterica strain

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag INN74_RS20710 Protein ID WP_000220578.1
Coordinates 4239698..4239982 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag INN74_RS20715 Protein ID WP_000212724.1
Coordinates 4239972..4240214 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN74_RS20695 (4234910) 4234910..4236562 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
INN74_RS20700 (4236971) 4236971..4239109 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
INN74_RS20705 (4239230) 4239230..4239694 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
INN74_RS20710 (4239698) 4239698..4239982 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INN74_RS20715 (4239972) 4239972..4240214 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
INN74_RS20720 (4240292) 4240292..4242205 - 1914 WP_001212137.1 BglG family transcription antiterminator -
INN74_RS20725 (4242222) 4242222..4242962 - 741 WP_000779263.1 KDGP aldolase family protein -
INN74_RS20730 (4242959) 4242959..4244077 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
INN74_RS20735 (4244061) 4244061..4245194 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T233875 WP_000220578.1 NZ_CP091571:c4239982-4239698 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T233875 NZ_LN832404:c3037126-3036719 [Escherichia coli K-12]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT233875 WP_000212724.1 NZ_CP091571:c4240214-4239972 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT233875 NZ_LN832404:c3037373-3037107 [Escherichia coli K-12]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References