Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3526522..3527142 Replicon chromosome
Accession NZ_CP091571
Organism Salmonella enterica strain

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag INN74_RS17435 Protein ID WP_001280991.1
Coordinates 3526924..3527142 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag INN74_RS17430 Protein ID WP_000344807.1
Coordinates 3526522..3526896 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN74_RS17420 (3521661) 3521661..3522854 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
INN74_RS17425 (3522877) 3522877..3526026 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
INN74_RS17430 (3526522) 3526522..3526896 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
INN74_RS17435 (3526924) 3526924..3527142 + 219 WP_001280991.1 HHA domain-containing protein Toxin
INN74_RS17440 (3527321) 3527321..3527872 + 552 WP_001278792.1 maltose O-acetyltransferase -
INN74_RS17445 (3527989) 3527989..3528459 + 471 WP_000136181.1 YlaC family protein -
INN74_RS17450 (3528515) 3528515..3528655 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
INN74_RS17455 (3528661) 3528661..3528921 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
INN74_RS17460 (3529146) 3529146..3530696 + 1551 WP_000213139.1 EAL domain-containing protein -
INN74_RS17470 (3530927) 3530927..3531316 + 390 WP_000961285.1 MGMT family protein -
INN74_RS17475 (3531349) 3531349..3531918 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T233870 WP_001280991.1 NZ_CP091571:3526924-3527142 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233870 NZ_LN832404:c2092401-2092147 [Escherichia coli K-12]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT233870 WP_000344807.1 NZ_CP091571:3526522-3526896 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT233870 NZ_LN832404:c2092649-2092398 [Escherichia coli K-12]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References