Detailed information of TA system TA023387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 96549..96997
• Replicon: plasmid pECOS88
• Accession: NC_011747
• Organism: Escherichia coli S88

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: ECS88_RS00640
• Protein ID: WP_000970009.1
• Coordinates: 96815..96997 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E1QMW3
• Locus tag: ECS88_RS00635
• Protein ID: WP_000079941.1
• Coordinates: 96549..96818 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECS88_RS27145	91880..92116	+	237	WP_001323890.1	colicin V immunity protein	-
ECS88_RS00615	92094..92405	+	312	WP_001259758.1	colicin V	-
ECS88_RS00620	92575..94689	-	2115	WP_001183604.1	peptidase domain-containing ABC transporter	-
ECS88_RS00625	94664..95938	-	1275	WP_000489608.1	HlyD family secretion protein	-
ECS88_RS00635	96549..96818	+	270	WP_000079941.1	hypothetical protein	Antitoxin
ECS88_RS00640	96815..96997	+	183	WP_000970009.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ECS88_RS00645	97096..97404	+	309	WP_000377483.1	hypothetical protein	-
ECS88_RS00660	97964..98998	+	1035	WP_001190234.1	3-deoxy-7-phosphoheptulonate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	sitABCD	iutA / iucD / iucC / iucB / iucA / iroN / iroE / iroD / iroC / iroB	1..133853	133853

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6917.00 Da
• Isoelectric Point: 4.2884

>T23387 WP_000970009.1 NC_011747:96815-96997 [Escherichia coli S88]
MMEIFWTMLASQDRNRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Nucleotide

• Length: 183 bp

>T23387 NC_011747:96815-96997 [Escherichia coli S88]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAATCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10252.58 Da
• Isoelectric Point: 7.2057

>AT23387 WP_000079941.1 NC_011747:96549-96818 [Escherichia coli S88]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT23387 NC_011747:96549-96818 [Escherichia coli S88]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A629TXC5