Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870306..870966 Replicon chromosome
Accession NZ_CP091571
Organism Salmonella enterica strain

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag INN74_RS04225 Protein ID WP_000244756.1
Coordinates 870553..870966 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag INN74_RS04220 Protein ID WP_000351186.1
Coordinates 870306..870572 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN74_RS04200 (866234) 866234..867667 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
INN74_RS04205 (867826) 867826..868137 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
INN74_RS04210 (868301) 868301..868960 + 660 WP_000250289.1 hemolysin III family protein -
INN74_RS04215 (869076) 869076..870056 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
INN74_RS04220 (870306) 870306..870572 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
INN74_RS04225 (870553) 870553..870966 + 414 WP_000244756.1 protein YgfX Toxin
INN74_RS04230 (871019) 871019..871540 - 522 WP_001055885.1 flavodoxin FldB -
INN74_RS04235 (871653) 871653..872549 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
INN74_RS04240 (872573) 872573..873286 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
INN74_RS04245 (873292) 873292..875025 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T233858 WP_000244756.1 NZ_CP091571:870553-870966 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T233858 NZ_LN831790:c5598794-5598531 [Streptomyces leeuwenhoekii]
ATGTCCATCACCGCCAGTGAGGCGCGCCAGAACCTGTTCCCGCTGATCGAGCAGGTCAACGAGGACCACGCTCCGGTGCA
CATCACCTCCCGCAAGGGGAACGCCGTCCTGATGTCCGAAGAGGACTTCAACTCCTGGACCGAGACAGTGCACCTCCTGC
GCTCTCCCAAGAACGCCCGTCGCCTGCTCGACTCCATCGCCGAGGCGGAGGCCGGCGAGGTTCAGCACCGCGAGCTGATC
GATCCCGACGCGGAGCGTGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT233858 WP_000351186.1 NZ_CP091571:870306-870572 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233858 NZ_LN831790:c5598534-5598280 [Streptomyces leeuwenhoekii]
GTGAGGATCTCGTTCACGTCCCACGCCTGGGGGGACTACACCTACTGGGCCGAGAGCGACCGCAAGATGGTCAAGCGCAT
CAACAAGCTGATCGACGACACGATGCGCGATCCCTTCAAGGGCATAGGCAAGCCGGAGCCCCTGAAGGGTGACCTGTCGG
GCTACTGGTCCCGGAGAATCGACGATACGCACCGGCTCGTGTACAAGCCGACCGACGACGAACTGATCATCGTCCAGGCG
CGGTACCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References