Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4421271..4422052 Replicon chromosome
Accession NZ_CP091569
Organism Salmonella enterica strain 131

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag INN75_RS21695 Protein ID WP_000626099.1
Coordinates 4421271..4421762 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag INN75_RS21700 Protein ID WP_001110452.1
Coordinates 4421759..4422052 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN75_RS21655 (4416457) 4416457..4416699 - 243 WP_197603740.1 hypothetical protein -
INN75_RS21660 (4416696) 4416696..4417052 - 357 WP_033567083.1 hypothetical protein -
INN75_RS21665 (4417049) 4417049..4417921 - 873 WP_033567082.1 ParA family protein -
INN75_RS21670 (4418112) 4418112..4418189 - 78 Protein_4245 helix-turn-helix domain-containing protein -
INN75_RS21675 (4418280) 4418280..4418612 - 333 WP_001165471.1 MerR family transcriptional regulator -
INN75_RS21680 (4418684) 4418684..4419061 + 378 WP_000916345.1 EthD family reductase -
INN75_RS21685 (4420094) 4420094..4420168 + 75 Protein_4248 porin family protein -
INN75_RS21690 (4420271) 4420271..4421023 + 753 WP_000842434.1 non-specific acid phosphatase -
INN75_RS21695 (4421271) 4421271..4421762 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
INN75_RS21700 (4421759) 4421759..4422052 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
INN75_RS21705 (4422369) 4422369..4422590 + 222 WP_001576552.1 hypothetical protein -
INN75_RS21710 (4422855) 4422855..4423730 + 876 WP_000921674.1 AraC family transcriptional regulator -
INN75_RS21715 (4423727) 4423727..4424014 + 288 WP_001269916.1 transcriptional regulator RtsB -
INN75_RS21720 (4424037) 4424037..4424252 + 216 WP_001595136.1 hypothetical protein -
INN75_RS21725 (4424260) 4424260..4424529 + 270 WP_010989096.1 hypothetical protein -
INN75_RS21730 (4424823) 4424823..4425728 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T233851 WP_000626099.1 NZ_CP091569:c4421762-4421271 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T233851 NZ_LN831039:c5732460-5732017 [Mycolicibacterium smegmatis]
ATGGCCAAACTTTCCGTCTCTGTCGAAGTTCCTTTGCCGCCGGAGCAGGCGTGGGAGTATGCCTCCGATCTGTCCCGGTA
CCACGAGTGGCTCAGCATTCACCGGGCCTGGCGCTCGAAGTTGCCCGAGACCCTGGAGAAGGGCACGGTGATCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGGTCAGGTGGACGCTGGTCCACTACAAGCCCCCGCAGGCGCTCACACTCAAC
GGTGACGGCCGCGGTGGGGTCAAGGTCAAGCTGATCGGCAAGATCAAGCCCACCGACAACGGCGCGACGGTGGGCTTCGA
CCTGCACCTCGGCGGCCCGGCCCTGTTCGGGCCCATCGGCATGGTGGTGGCCGCGGCGCTCAAGAGCGACATCCAGGAGT
CGCTCAACCGCTTCAAGCAGCTCTACGCCCCGTCCGCGACCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT233851 WP_001110452.1 NZ_CP091569:c4422052-4421759 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT233851 NZ_LN831039:c5732658-5732470 [Mycolicibacterium smegmatis]
ATGGGATTCCTGGACAAGGCCAAAGACCTCTTGTCGCAGAACGCCGACAAGGTGGACACCGTCATTGACAAGGCCGGCGA
CATGATCGACGAGAAGACGCAGGGCAAGTACGCCCAGCACGTCGACAAGGCGCAGGACGCCGCGAAGAACGCCATCCGCA
AAGACGACCCTCAAGAACCACAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References