Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4211193..4211709 Replicon chromosome
Accession NZ_CP091569
Organism Salmonella enterica strain 131

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag INN75_RS20590 Protein ID WP_000220578.1
Coordinates 4211193..4211477 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag INN75_RS20595 Protein ID WP_000212724.1
Coordinates 4211467..4211709 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN75_RS20575 (4206405) 4206405..4208057 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
INN75_RS20580 (4208466) 4208466..4210604 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
INN75_RS20585 (4210725) 4210725..4211189 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
INN75_RS20590 (4211193) 4211193..4211477 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INN75_RS20595 (4211467) 4211467..4211709 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
INN75_RS20600 (4211787) 4211787..4213700 - 1914 WP_001212137.1 BglG family transcription antiterminator -
INN75_RS20605 (4213717) 4213717..4214457 - 741 WP_000779263.1 KDGP aldolase family protein -
INN75_RS20610 (4214454) 4214454..4215572 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
INN75_RS20615 (4215556) 4215556..4216689 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T233850 WP_000220578.1 NZ_CP091569:c4211477-4211193 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T233850 NZ_LN831039:4529168-4529497 [Mycolicibacterium smegmatis]
GTGCGGCGCGGCGATATCTACACCGCGGCGGCGCGAGGTGCGTACACCGGCAAGCCTCGGCCGGTCCTCATCATCCAGGA
CGACCGATTCGATGCCACCGCGTCGGTCACCGTCGTGCCGTTTACGACAAGCGACACCGACGCACCGCTTCTGCGAATTC
GAATCGAGCCAACGCCAGCCACCGGACTCTCCACAGTCAGCTCGTTGATGATCGACAAGGTGACCACAGTTCCCCGCTCC
AGCTTGACGCACCGTGTCGGCCGACTGGCGGAGACAGACATGGTCAGGACCGACCGCGCACTCCTGGTTTTTCTGGGAAT
CGCCGGGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT233850 WP_000212724.1 NZ_CP091569:c4211709-4211467 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT233850 NZ_LN831039:4528956-4529165 [Mycolicibacterium smegmatis]
ATGACTCCCGCGCGTGACCGAGTACGCCGACATCGCGAGCGGCTGCGGCGACAAGGTCTGCGGCCGGTGCAGATCTGGGT
CCCCGACGTGAATGCACCCGAATTTCGCCGGGAGGCGCACCGGCAGTCTGAGTTGGTCGCCGCCGGCGAGCATGAGGCCG
AAGATCAAGCTTTCGTCGACGCGATCTCCGTCGACTGGGACGACGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References