Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3498017..3498637 Replicon chromosome
Accession NZ_CP091569
Organism Salmonella enterica strain 131

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag INN75_RS17315 Protein ID WP_001280991.1
Coordinates 3498419..3498637 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag INN75_RS17310 Protein ID WP_000344807.1
Coordinates 3498017..3498391 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN75_RS17300 (3493156) 3493156..3494349 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
INN75_RS17305 (3494372) 3494372..3497521 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
INN75_RS17310 (3498017) 3498017..3498391 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
INN75_RS17315 (3498419) 3498419..3498637 + 219 WP_001280991.1 HHA domain-containing protein Toxin
INN75_RS17320 (3498816) 3498816..3499367 + 552 WP_001278792.1 maltose O-acetyltransferase -
INN75_RS17325 (3499484) 3499484..3499954 + 471 WP_000136181.1 YlaC family protein -
INN75_RS17330 (3500010) 3500010..3500150 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
INN75_RS17335 (3500156) 3500156..3500416 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
INN75_RS17340 (3500641) 3500641..3502191 + 1551 WP_000213139.1 EAL domain-containing protein -
INN75_RS17350 (3502422) 3502422..3502811 + 390 WP_000961285.1 MGMT family protein -
INN75_RS17355 (3502844) 3502844..3503413 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T233845 WP_001280991.1 NZ_CP091569:3498419-3498637 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233845 NZ_LN831036:c2516646-2516380 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT233845 WP_000344807.1 NZ_CP091569:3498017-3498391 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT233845 NZ_LN831036:c2516903-2516646 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References