Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 871378..872038 Replicon chromosome
Accession NZ_CP091569
Organism Salmonella enterica strain 131

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag INN75_RS04235 Protein ID WP_000244756.1
Coordinates 871625..872038 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag INN75_RS04230 Protein ID WP_000351186.1
Coordinates 871378..871644 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN75_RS04210 (867306) 867306..868739 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
INN75_RS04215 (868898) 868898..869209 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
INN75_RS04220 (869373) 869373..870032 + 660 WP_000250289.1 hemolysin III family protein -
INN75_RS04225 (870148) 870148..871128 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
INN75_RS04230 (871378) 871378..871644 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
INN75_RS04235 (871625) 871625..872038 + 414 WP_000244756.1 protein YgfX Toxin
INN75_RS04240 (872091) 872091..872612 - 522 WP_001055885.1 flavodoxin FldB -
INN75_RS04245 (872725) 872725..873621 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
INN75_RS04250 (873645) 873645..874358 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
INN75_RS04255 (874364) 874364..876097 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T233833 WP_000244756.1 NZ_CP091569:871625-872038 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T233833 NZ_LN831035:1297673-1297978 [Haemophilus influenzae]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCTATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT233833 WP_000351186.1 NZ_CP091569:871378-871644 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233833 NZ_LN831035:1297989-1298312 [Haemophilus influenzae]
ATGATGACGAGAAAACCCACCTCTGTTGGTGAAATTCTACAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAGTGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGCAATATTGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGTATTTGATACTACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGATACTTCTACATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References