233819

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 3688975..3689497 Replicon chromosome
Accession NZ_CP091566
Organism Salmonella enterica strain 137

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag INN76_RS17975 Protein ID WP_000221343.1
Coordinates 3688975..3689259 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag INN76_RS17980 Protein ID WP_000885424.1
Coordinates 3689249..3689497 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN76_RS17955 (3685050) 3685050..3686558 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
INN76_RS17960 (3686603) 3686603..3687091 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
INN76_RS17965 (3687284) 3687284..3688363 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
INN76_RS17970 (3688415) 3688415..3688804 - 390 WP_000194089.1 RidA family protein -
INN76_RS17975 (3688975) 3688975..3689259 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INN76_RS17980 (3689249) 3689249..3689497 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
INN76_RS17985 (3689649) 3689649..3689864 + 216 WP_000206207.1 hypothetical protein -
INN76_RS17990 (3689854) 3689854..3690186 + 333 WP_000253154.1 DUF1493 family protein -
INN76_RS17995 (3690329) 3690329..3691237 + 909 WP_010989018.1 hypothetical protein -
INN76_RS18000 (3691293) 3691293..3692007 - 715 Protein_3509 helix-turn-helix domain-containing protein -
INN76_RS18005 (3692815) 3692815..3694281 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T233819 WP_000221343.1 NZ_CP091566:c3689259-3688975 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T233819 NZ_LN831026:c715083-714631 [Corynebacterium diphtheriae]
GTGTCGGGAAATAGCGGGGCGTCACCGCAGGACATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTG
CGGGAAGCGAACAGGTCCTCACAGAGAACCTGAACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCG
CGATCGCTTCAGTATTTCAATCGTCGTTTGGCGTCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTC
AAGCTGGCAAACGGGCATTACTTCCAAGACGGAAACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAA
TAACGTTCACGTCAGTCCCCCTCGGTCTGATGACGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAG
AAAACGGGATAGCGTTCGTTAGACAAAAGCTTTTGGACTGGACCGTAGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT233819 WP_000885424.1 NZ_CP091566:c3689497-3689249 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT233819 NZ_LN831026:c715661-715095 [Corynebacterium diphtheriae]
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTAAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTGCCT
TCCATGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References