Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2640798..2641418 Replicon chromosome
Accession NZ_CP091566
Organism Salmonella enterica strain 137

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag INN76_RS12705 Protein ID WP_001280991.1
Coordinates 2640798..2641016 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag INN76_RS12710 Protein ID WP_000344807.1
Coordinates 2641044..2641418 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN76_RS12665 (2636022) 2636022..2636591 + 570 WP_000779803.1 YbaY family lipoprotein -
INN76_RS12670 (2636624) 2636624..2637013 - 390 WP_000961285.1 MGMT family protein -
INN76_RS12680 (2637244) 2637244..2638794 - 1551 WP_000213139.1 EAL domain-containing protein -
INN76_RS12685 (2639019) 2639019..2639279 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
INN76_RS12690 (2639285) 2639285..2639425 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
INN76_RS12695 (2639481) 2639481..2639951 - 471 WP_000136181.1 YlaC family protein -
INN76_RS12700 (2640068) 2640068..2640619 - 552 WP_001278792.1 maltose O-acetyltransferase -
INN76_RS12705 (2640798) 2640798..2641016 - 219 WP_001280991.1 HHA domain-containing protein Toxin
INN76_RS12710 (2641044) 2641044..2641418 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
INN76_RS12715 (2641914) 2641914..2645063 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
INN76_RS12720 (2645086) 2645086..2646279 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T233818 WP_001280991.1 NZ_CP091566:c2641016-2640798 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233818 NZ_LN831026:101411-101674 [Corynebacterium diphtheriae]
GTGGCTTGGGAGATTAGTTTTTCTCCTCGGGCGGTGAAGTCGTTTAAGAAGCTCGATACGGGTGAGCAGCGGAGGGTGAG
TAAGTTTCTGCGGGAGGTTGGCGCCCTTGAGGACCCGAGGTTACGAGGTAAGGCATTAACAGCCAATAAGTCGGGTTTGT
GGCGCTGGCGTGTGGGGGACTATCGGATTATTGCTGACATTGTGGACGCGCGTGTTGTCGTCGTTGTGGTTGACGTTGGG
CACCGCTCGAAGGCCTACGACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT233818 WP_000344807.1 NZ_CP091566:c2641418-2641044 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT233818 NZ_LN831026:101191-101427 [Corynebacterium diphtheriae]
ATGAGTGGTTCGGTGATTAGCTTGCGTATCGATGACGAGCAGAAGCGGCGTTTGGATGAGCTGTCGCGACGTACGGGGCG
GCCGTGTTCGTTTTATCTTCGGGAAGCGTTGAGTGCACATCTGGCTGATCTGGAGTATGTGTATCGCTTGGAGGAGGAGG
CTGCTCAGGTTCGTCGCGGGGAGTTGGGAACTGTGCCGTTGAGTCAGCTGGAGCGCGAGTGTGGCTTGGGAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References