Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4876060..4876874 Replicon chromosome
Accession NC_011742
Organism Escherichia coli S88

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag ECS88_RS26255 Protein ID WP_001054376.1
Coordinates 4876617..4876874 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID B7MMJ3
Locus tag ECS88_RS26250 Protein ID WP_001338189.1
Coordinates 4876060..4876605 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECS88_RS26220 4871751..4873064 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
ECS88_RS26225 4873076..4873354 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ECS88_RS26230 4873351..4874472 - 1122 WP_000010829.1 M42 family metallopeptidase -
ECS88_RS27750 4874717..4874833 - 117 Protein_4654 VOC family protein -
ECS88_RS26240 4874871..4875089 - 219 Protein_4655 hypothetical protein -
ECS88_RS26245 4875258..4876004 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
ECS88_RS26250 4876060..4876605 - 546 WP_001338189.1 N-acetyltransferase Antitoxin
ECS88_RS26255 4876617..4876874 - 258 WP_001054376.1 hypothetical protein Toxin
ECS88_RS26265 4877251..4877496 - 246 Protein_4659 GNAT family N-acetyltransferase -
ECS88_RS26275 4877612..4878852 + 1241 Protein_4660 helicase YjhR -
ECS88_RS26285 4879435..4880415 - 981 WP_000991455.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ECS88_RS26290 4880480..4881586 - 1107 WP_001299704.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB / fimE 4876060..4885451 9391


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T23381 WP_001054376.1 NC_011742:c4876874-4876617 [Escherichia coli S88]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T23381 NC_011742:c4876874-4876617 [Escherichia coli S88]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19986.92 Da        Isoelectric Point: 6.3277

>AT23381 WP_001338189.1 NC_011742:c4876605-4876060 [Escherichia coli S88]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT23381 NC_011742:c4876605-4876060 [Escherichia coli S88]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTTAGCAAAGAAGCCGATTTAGTGACCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2KXJ3

References