Detailed information of TA system TA233809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1033557..1034317
• Replicon: chromosome
• Accession: NZ_CP091566
• Organism: Salmonella enterica strain 137

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: Q57IH1
• Locus tag: INN76_RS05085
• Protein ID: WP_000533909.1
• Coordinates: 1033557..1034042 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: M7RHS4
• Locus tag: INN76_RS05090
• Protein ID: WP_000965886.1
• Coordinates: 1034030..1034317 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN76_RS05055 (1028627)	1028627..1029289	+	663	WP_000747548.1	OmpA family lipoprotein	-
INN76_RS05060 (1029508)	1029508..1030482	+	975	WP_000804674.1	glyoxylate/hydroxypyruvate reductase GhrB	-
INN76_RS05065 (1030532)	1030532..1031242	-	711	WP_000190524.1	DUF3053 domain-containing protein	-
INN76_RS05070 (1031681)	1031681..1031971	+	291	WP_000455790.1	HTH-type transcriptional regulator	-
INN76_RS05075 (1032260)	1032260..1032472	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
INN76_RS05080 (1032646)	1032646..1033185	+	540	WP_000047149.1	copper-binding periplasmic metallochaperone CueP	-
INN76_RS05085 (1033557)	1033557..1034042	-	486	WP_000533909.1	GNAT family N-acetyltransferase	Toxin
INN76_RS05090 (1034030)	1034030..1034317	-	288	WP_000965886.1	DUF1778 domain-containing protein	Antitoxin
INN76_RS05095 (1034495)	1034495..1034962	-	468	WP_000702452.1	GNAT family N-acetyltransferase	-
INN76_RS05100 (1035134)	1035134..1035409	-	276	Protein_1001	IS3 family transposase	-
INN76_RS05105 (1035591)	1035591..1037660	-	2070	WP_001291736.1	glycine--tRNA ligase subunit beta	-
INN76_RS05110 (1037670)	1037670..1038581	-	912	WP_001168551.1	glycine--tRNA ligase subunit alpha	-
INN76_RS05115 (1038720)	1038720..1039022	-	303	WP_000605590.1	YsaB family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1024122..1034962	10840

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (31-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-94)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17703.41 Da
• Isoelectric Point: 9.8719

>T233809 WP_000533909.1 NZ_CP091566:c1034042-1033557 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T233809 NZ_LN824140:1064636-1064944 [Bifidobacterium longum subsp. infantis]
ATGGAAATCAAGCAATCCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGGACCACAAAGCGAAGGCCGCCATCCAAGC
CCGGCTCGATGTCTGCAAGCTCGCAGGCAGGCCATTCGGCGACATCAAACCCGTGGGAGGCCCGGTCAGCGAGATGCGGT
TCCACACCGGGGCCGGATACCGCGTCTACTTCGCCATGCAGGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAA
AGCACCCAGCAGACCGACATCAGACAAGCCCACGACATCCTCAACGACTACAAGGAACAACGACAATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10950.60 Da
• Isoelectric Point: 4.6811

>AT233809 WP_000965886.1 NZ_CP091566:c1034317-1034030 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Nucleotide

• Length: 288 bp

>AT233809 NZ_LN824140:1064941-1065225 [Bifidobacterium longum subsp. infantis]
ATGAGCACCGAATTCACCGACTACGACACCAGCGAATACCTCGAAAACGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATACGACGACCCCGCACTCATGCAGGCCGCGCTCGGCAACGTCGCCAAGGCCCGGGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAGAGCCTCAGCAAGGACGGCAACCCCAGCTTCCAAACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Structures

Toxin

• PDB: 7F36
• PDB: 7AK8
• PDB: 5FVJ

Antitoxin

• AlphaFold DB: A0A3V2JDX2