Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1033557..1034317 Replicon chromosome
Accession NZ_CP091566
Organism Salmonella enterica strain 137

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag INN76_RS05085 Protein ID WP_000533909.1
Coordinates 1033557..1034042 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag INN76_RS05090 Protein ID WP_000965886.1
Coordinates 1034030..1034317 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN76_RS05055 (1028627) 1028627..1029289 + 663 WP_000747548.1 OmpA family lipoprotein -
INN76_RS05060 (1029508) 1029508..1030482 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
INN76_RS05065 (1030532) 1030532..1031242 - 711 WP_000190524.1 DUF3053 domain-containing protein -
INN76_RS05070 (1031681) 1031681..1031971 + 291 WP_000455790.1 HTH-type transcriptional regulator -
INN76_RS05075 (1032260) 1032260..1032472 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
INN76_RS05080 (1032646) 1032646..1033185 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
INN76_RS05085 (1033557) 1033557..1034042 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
INN76_RS05090 (1034030) 1034030..1034317 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
INN76_RS05095 (1034495) 1034495..1034962 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
INN76_RS05100 (1035134) 1035134..1035409 - 276 Protein_1001 IS3 family transposase -
INN76_RS05105 (1035591) 1035591..1037660 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
INN76_RS05110 (1037670) 1037670..1038581 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
INN76_RS05115 (1038720) 1038720..1039022 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1024122..1034962 10840


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T233809 WP_000533909.1 NZ_CP091566:c1034042-1033557 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T233809 NZ_LN824140:1064636-1064944 [Bifidobacterium longum subsp. infantis]
ATGGAAATCAAGCAATCCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGGACCACAAAGCGAAGGCCGCCATCCAAGC
CCGGCTCGATGTCTGCAAGCTCGCAGGCAGGCCATTCGGCGACATCAAACCCGTGGGAGGCCCGGTCAGCGAGATGCGGT
TCCACACCGGGGCCGGATACCGCGTCTACTTCGCCATGCAGGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAA
AGCACCCAGCAGACCGACATCAGACAAGCCCACGACATCCTCAACGACTACAAGGAACAACGACAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT233809 WP_000965886.1 NZ_CP091566:c1034317-1034030 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT233809 NZ_LN824140:1064941-1065225 [Bifidobacterium longum subsp. infantis]
ATGAGCACCGAATTCACCGACTACGACACCAGCGAATACCTCGAAAACGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATACGACGACCCCGCACTCATGCAGGCCGCGCTCGGCAACGTCGCCAAGGCCCGGGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAGAGCCTCAGCAAGGACGGCAACCCCAGCTTCCAAACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References