Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 289140..289800 Replicon chromosome
Accession NZ_CP091566
Organism Salmonella enterica strain 137

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag INN76_RS01395 Protein ID WP_000244756.1
Coordinates 289140..289553 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag INN76_RS01400 Protein ID WP_000351186.1
Coordinates 289534..289800 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN76_RS01375 (285081) 285081..286814 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
INN76_RS01380 (286820) 286820..287533 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
INN76_RS01385 (287557) 287557..288453 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
INN76_RS01390 (288566) 288566..289087 + 522 WP_001055885.1 flavodoxin FldB -
INN76_RS01395 (289140) 289140..289553 - 414 WP_000244756.1 protein YgfX Toxin
INN76_RS01400 (289534) 289534..289800 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
INN76_RS01405 (290050) 290050..291030 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
INN76_RS01410 (291146) 291146..291805 - 660 WP_000250289.1 hemolysin III family protein -
INN76_RS01415 (291969) 291969..292280 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
INN76_RS01420 (292439) 292439..293872 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T233806 WP_000244756.1 NZ_CP091566:c289553-289140 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T233806 NZ_LN824140:c333341-333057 [Bifidobacterium longum subsp. infantis]
ATGAGCACCGAAATCACCGACTACGACACCAGCGAATACCTCGAAAACGAACAGGACATCATCGCCTACCTCAACGCCAT
AGCCGAATACGACGACCCCGCACTCATGCAGGCCGCACTCGGCAACGTCGCCAAGGCTCGAGGCATGACCCAGATCGCCA
AGGACGCGGGCGTGGGGCGCGAAAGCCTCTACAAAAGCCTCAGCAAGGACGGAAACCCCAGCTTCCAGACCATCGCCAAG
GTAATCCACGCCCTCGGCGGACGCCTCACCATCCAAGCCGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT233806 WP_000351186.1 NZ_CP091566:c289800-289534 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233806 NZ_LN824140:c333643-333338 [Bifidobacterium longum subsp. infantis]
ATGGAAATCAAGCAAACCGCCGAATACCGCAAGTGGTTCAAGAAACTCAGGAACCGCGAGGCGAAAGCCGCCATCCAAGC
CCGGCTCGACGCCTGCAAGCTCGCCGGCAGGCCGTTCGGCGACATCAAACCCGTGGGAGGCCCGGTCAGCGAGATGCGGT
TCCACATCGGAGCCGGATACCGCGTCTACTTCACCACGCGCGGCAACGTGCTCATGCTGCTGCTCGCAGGCGGCGACAAA
AGCACCCAGCAGACCGACATCAAACAAGCCCACGCCATACTCGACGACTACAAGGAGCAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References