233794

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4586474..4587234 Replicon chromosome
Accession NZ_CP091563
Organism Salmonella enterica strain 143

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag INN77_RS22670 Protein ID WP_000533909.1
Coordinates 4586474..4586959 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag INN77_RS22675 Protein ID WP_000965886.1
Coordinates 4586947..4587234 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN77_RS22640 (4581544) 4581544..4582206 + 663 WP_000747548.1 OmpA family lipoprotein -
INN77_RS22645 (4582425) 4582425..4583399 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
INN77_RS22650 (4583449) 4583449..4584159 - 711 WP_000190524.1 DUF3053 domain-containing protein -
INN77_RS22655 (4584598) 4584598..4584888 + 291 WP_000455790.1 HTH-type transcriptional regulator -
INN77_RS22660 (4585177) 4585177..4585389 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
INN77_RS22665 (4585563) 4585563..4586102 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
INN77_RS22670 (4586474) 4586474..4586959 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
INN77_RS22675 (4586947) 4586947..4587234 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
INN77_RS22680 (4587412) 4587412..4587879 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
INN77_RS22685 (4588051) 4588051..4588326 - 276 Protein_4436 IS3 family transposase -
INN77_RS22690 (4588508) 4588508..4590577 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
INN77_RS22695 (4590587) 4590587..4591498 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
INN77_RS22700 (4591637) 4591637..4591939 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T233794 WP_000533909.1 NZ_CP091563:c4586959-4586474 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T233794 NZ_LN824133:c1305943-1305725 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT233794 WP_000965886.1 NZ_CP091563:c4587234-4586947 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT233794 NZ_LN824133:c1306344-1305970 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References