Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3874033..3874693 Replicon chromosome
Accession NZ_CP091563
Organism Salmonella enterica strain 143

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag INN77_RS19175 Protein ID WP_000244756.1
Coordinates 3874033..3874446 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag INN77_RS19180 Protein ID WP_000351186.1
Coordinates 3874427..3874693 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN77_RS19155 (3869974) 3869974..3871707 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
INN77_RS19160 (3871713) 3871713..3872426 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
INN77_RS19165 (3872450) 3872450..3873346 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
INN77_RS19170 (3873459) 3873459..3873980 + 522 WP_001055885.1 flavodoxin FldB -
INN77_RS19175 (3874033) 3874033..3874446 - 414 WP_000244756.1 protein YgfX Toxin
INN77_RS19180 (3874427) 3874427..3874693 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
INN77_RS19185 (3874943) 3874943..3875923 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
INN77_RS19190 (3876039) 3876039..3876698 - 660 WP_000250289.1 hemolysin III family protein -
INN77_RS19195 (3876862) 3876862..3877173 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
INN77_RS19200 (3877332) 3877332..3878765 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T233791 WP_000244756.1 NZ_CP091563:c3874446-3874033 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T233791 NZ_LN824133:43269-43652 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT233791 WP_000351186.1 NZ_CP091563:c3874693-3874427 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233791 NZ_LN824133:43027-43269 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References