233780

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2289722..2290244 Replicon chromosome
Accession NZ_CP091563
Organism Salmonella enterica strain 143

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag INN77_RS11300 Protein ID WP_000221343.1
Coordinates 2289722..2290006 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag INN77_RS11305 Protein ID WP_000885424.1
Coordinates 2289996..2290244 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN77_RS11280 (2285797) 2285797..2287305 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
INN77_RS11285 (2287350) 2287350..2287838 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
INN77_RS11290 (2288031) 2288031..2289110 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
INN77_RS11295 (2289162) 2289162..2289551 - 390 WP_000194089.1 RidA family protein -
INN77_RS11300 (2289722) 2289722..2290006 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INN77_RS11305 (2289996) 2289996..2290244 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
INN77_RS11310 (2290396) 2290396..2290611 + 216 WP_000206207.1 hypothetical protein -
INN77_RS11315 (2290601) 2290601..2290933 + 333 WP_000253154.1 DUF1493 family protein -
INN77_RS11320 (2291076) 2291076..2291984 + 909 WP_010989018.1 hypothetical protein -
INN77_RS11325 (2292040) 2292040..2292754 - 715 Protein_2208 helix-turn-helix domain-containing protein -
INN77_RS11330 (2293562) 2293562..2295028 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T233780 WP_000221343.1 NZ_CP091563:c2290006-2289722 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T233780 NZ_CP091563:c2290006-2289722 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT233780 WP_000885424.1 NZ_CP091563:c2290244-2289996 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT233780 NZ_CP091563:c2290244-2289996 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References