Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1241543..1242163 Replicon chromosome
Accession NZ_CP091563
Organism Salmonella enterica strain 143

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag INN77_RS06030 Protein ID WP_001280991.1
Coordinates 1241543..1241761 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag INN77_RS06035 Protein ID WP_000344807.1
Coordinates 1241789..1242163 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN77_RS05990 (1236767) 1236767..1237336 + 570 WP_000779803.1 YbaY family lipoprotein -
INN77_RS05995 (1237369) 1237369..1237758 - 390 WP_000961285.1 MGMT family protein -
INN77_RS06005 (1237989) 1237989..1239539 - 1551 WP_000213139.1 EAL domain-containing protein -
INN77_RS06010 (1239764) 1239764..1240024 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
INN77_RS06015 (1240030) 1240030..1240170 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
INN77_RS06020 (1240226) 1240226..1240696 - 471 WP_000136181.1 YlaC family protein -
INN77_RS06025 (1240813) 1240813..1241364 - 552 WP_001278792.1 maltose O-acetyltransferase -
INN77_RS06030 (1241543) 1241543..1241761 - 219 WP_001280991.1 HHA domain-containing protein Toxin
INN77_RS06035 (1241789) 1241789..1242163 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
INN77_RS06040 (1242659) 1242659..1245808 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
INN77_RS06045 (1245831) 1245831..1247024 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T233779 WP_001280991.1 NZ_CP091563:c1241761-1241543 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233779 NZ_LN681227:4421050-4421550 [Xenorhabdus nematophila AN6/1]
ATGATTCTTTCGGCACCGGAATTGCTGTCTGAACACCATTATCGTGAAGCGTTTAATTCAGGGGTTACCACCCTAGACCA
GTGGCTCAAAAATCGTGCACTAAAAAATAACTTAACTGGCGCATCAAAAACCTACGTGGTTTGTAGTGAAAATCGAGTAC
TGGCTTATTATTCTCTGGCCGCTAGCGCGATTGTGACTGATTCGACACCCGGCCATTTTAGGCGGAATATGCCTAACCCA
ATCCCTGTCGTCGTTTTAGGCCGATTGGCTGTAGATAGGAGTCTGCAACGAAAAGGCATAGGCCGTGCGTTAGTACAAGA
TGCCGCGTTGAGAATAATCCAAGCTGCTGATTTAATTGGTGTCCGAGGTATGATTATTCATGCGCTTTCAGATGAAGTAA
AATCTTTTTATGAAACCATCGGGTTTGAACCTTCTCCTCTCGATCCCATGTTACTGATGGCTACACTCGCAGATTTAAAA
AGATCCTGTACGAATAGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT233779 WP_000344807.1 NZ_CP091563:c1242163-1241789 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT233779 NZ_LN681227:4420775-4421053 [Xenorhabdus nematophila AN6/1]
ATGCAAACGCCAAAGCGAGATACTTTGAGTATTCGTATCAAACCAGAAACTCGGAATTTGATTGATAAAGCAGCCGCCAT
TCAGGGTAAAAACCGCACAGATTTTGTATTGGAAGCGGCACAACGCATGGCCGAAGAAACCTTGCTTGAACAAGCAATTA
TGACGGCCAGTCCAGAAGCATATGCCAAATTTTTGGATCGTTTAGATATGCCTCCACAACCGAATAAGCAATTGCGAGAA
ACCATGCAGATGGAAACGCCTTGGGGCAAGGAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References