Detailed information of TA system TA233779

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1241543..1242163
• Replicon: chromosome
• Accession: NZ_CP091563
• Organism: Salmonella enterica strain 143

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: INN77_RS06030
• Protein ID: WP_001280991.1
• Coordinates: 1241543..1241761 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: INN77_RS06035
• Protein ID: WP_000344807.1
• Coordinates: 1241789..1242163 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN77_RS05990 (1236767)	1236767..1237336	+	570	WP_000779803.1	YbaY family lipoprotein	-
INN77_RS05995 (1237369)	1237369..1237758	-	390	WP_000961285.1	MGMT family protein	-
INN77_RS06005 (1237989)	1237989..1239539	-	1551	WP_000213139.1	EAL domain-containing protein	-
INN77_RS06010 (1239764)	1239764..1240024	+	261	WP_000801415.1	type B 50S ribosomal protein L31	-
INN77_RS06015 (1240030)	1240030..1240170	+	141	WP_001197749.1	type B 50S ribosomal protein L36	-
INN77_RS06020 (1240226)	1240226..1240696	-	471	WP_000136181.1	YlaC family protein	-
INN77_RS06025 (1240813)	1240813..1241364	-	552	WP_001278792.1	maltose O-acetyltransferase	-
INN77_RS06030 (1241543)	1241543..1241761	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
INN77_RS06035 (1241789)	1241789..1242163	-	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
INN77_RS06040 (1242659)	1242659..1245808	-	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
INN77_RS06045 (1245831)	1245831..1247024	-	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T233779 WP_001280991.1 NZ_CP091563:c1241761-1241543 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T233779 NZ_LN681227:4421050-4421550 [Xenorhabdus nematophila AN6/1]
ATGATTCTTTCGGCACCGGAATTGCTGTCTGAACACCATTATCGTGAAGCGTTTAATTCAGGGGTTACCACCCTAGACCA
GTGGCTCAAAAATCGTGCACTAAAAAATAACTTAACTGGCGCATCAAAAACCTACGTGGTTTGTAGTGAAAATCGAGTAC
TGGCTTATTATTCTCTGGCCGCTAGCGCGATTGTGACTGATTCGACACCCGGCCATTTTAGGCGGAATATGCCTAACCCA
ATCCCTGTCGTCGTTTTAGGCCGATTGGCTGTAGATAGGAGTCTGCAACGAAAAGGCATAGGCCGTGCGTTAGTACAAGA
TGCCGCGTTGAGAATAATCCAAGCTGCTGATTTAATTGGTGTCCGAGGTATGATTATTCATGCGCTTTCAGATGAAGTAA
AATCTTTTTATGAAACCATCGGGTTTGAACCTTCTCCTCTCGATCCCATGTTACTGATGGCTACACTCGCAGATTTAAAA
AGATCCTGTACGAATAGTTAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT233779 WP_000344807.1 NZ_CP091563:c1242163-1241789 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT233779 NZ_LN681227:4420775-4421053 [Xenorhabdus nematophila AN6/1]
ATGCAAACGCCAAAGCGAGATACTTTGAGTATTCGTATCAAACCAGAAACTCGGAATTTGATTGATAAAGCAGCCGCCAT
TCAGGGTAAAAACCGCACAGATTTTGTATTGGAAGCGGCACAACGCATGGCCGAAGAAACCTTGCTTGAACAAGCAATTA
TGACGGCCAGTCCAGAAGCATATGCCAAATTTTTGGATCGTTTAGATATGCCTCCACAACCGAATAAGCAATTGCGAGAA
ACCATGCAGATGGAAACGCCTTGGGGCAAGGAATTATGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0