Detailed information of TA system TA233775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 583700..584276
• Replicon: chromosome
• Accession: NZ_CP091563
• Organism: Salmonella enterica strain 143

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: M7RG88
• Locus tag: INN77_RS02850
• Protein ID: WP_001131963.1
• Coordinates: 583700..583987 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: B5R9R5
• Locus tag: INN77_RS02855
• Protein ID: WP_000063142.1
• Coordinates: 583974..584276 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN77_RS02840 (578810)	578810..582319	-	3510	WP_001043484.1	type I restriction-modification system endonuclease	-
INN77_RS02845 (582517)	582517..583431	+	915	WP_000290512.1	restriction endonuclease	-
INN77_RS02850 (583700)	583700..583987	+	288	WP_001131963.1	BrnT family toxin	Toxin
INN77_RS02855 (583974)	583974..584276	+	303	WP_000063142.1	BrnA antitoxin family protein	Antitoxin
INN77_RS02860 (584351)	584351..585307	-	957	WP_000187839.1	GTPase	-
INN77_RS02865 (585318)	585318..585521	-	204	WP_000460616.1	YbdD/YjiX family protein	-
INN77_RS02870 (585616)	585616..587766	-	2151	WP_000379927.1	pyruvate/proton symporter BtsT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (37-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11294.80 Da
• Isoelectric Point: 9.5894

>T233775 WP_001131963.1 NZ_CP091563:583700-583987 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Nucleotide

• Length: 288 bp

>T233775 NZ_LN681227:3606774-3607028 [Xenorhabdus nematophila AN6/1]
ATGAATGTTATGAGCTATTCAGCATTTCGAACTCATTTAGCTAAAACTCTGGATAAAGTGAACGATGACCACCAACCCGT
GATGATCACTCGTCAGAATGGTAAGCCAGCAGTTGTACTCAGTTTGGAGGATTTTCGGGCTTATGAAGAAACTGCCTATT
TGATGGCAAGCCCTAAAAATGCAACGCGCCTAAACCAAGCTATTGCAGAGGTAGAAAATGGTAAAACTCTTGAAAAAGAC
TTACTGGAAGAATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11373.96 Da
• Isoelectric Point: 10.1293

>AT233775 WP_000063142.1 NZ_CP091563:583974-584276 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Nucleotide

• Length: 303 bp

>AT233775 NZ_LN681227:3607025-3607279 [Xenorhabdus nematophila AN6/1]
ATGATTCTATCTTGGGCAGAAACAGCGTGGGAAGATTATCTTTATTGGCAACAAACCGATAAAAAAACCCTAAAACGCAT
TAATACTCTTATTAAGGATATTGCCCGACAGTCTTTTGATGGGCTAGGTGATCCTGAACCCTTAAAACATAACTGGTCAG
GATACTGGTCCAGGCGGATTGATCGTGAGCATCGCCTAGTTTATAAGGTTACAGACACCGCAATAATTATTGTTCAATGT
CGCTATCACTACTAA

Structures

Toxin

• PDB: 7VD7

Antitoxin

• AlphaFold DB: A0A4D6PB01