Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 489499..490015 Replicon chromosome
Accession NZ_CP091563
Organism Salmonella enterica strain 143

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag INN77_RS02455 Protein ID WP_000220578.1
Coordinates 489731..490015 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag INN77_RS02450 Protein ID WP_000212724.1
Coordinates 489499..489741 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN77_RS02430 (484519) 484519..485652 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
INN77_RS02435 (485636) 485636..486754 + 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
INN77_RS02440 (486751) 486751..487491 + 741 WP_000779263.1 KDGP aldolase family protein -
INN77_RS02445 (487508) 487508..489421 + 1914 WP_001212137.1 BglG family transcription antiterminator -
INN77_RS02450 (489499) 489499..489741 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
INN77_RS02455 (489731) 489731..490015 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INN77_RS02460 (490019) 490019..490483 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
INN77_RS02465 (490604) 490604..492742 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
INN77_RS02470 (493151) 493151..494803 - 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T233774 WP_000220578.1 NZ_CP091563:489731-490015 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T233774 NZ_LN681227:c2939532-2939248 [Xenorhabdus nematophila AN6/1]
ATGACTTATAGTCTCAAATTTGAAAAGCGGGCACTAAAAGAGTGGGAAAAACTAGGGCATCCTATCCGTGAGCAGTTCAA
AAAGAAATTGTCTGAGCGTTTAGAAAACCCCCATATATCTTCAGCTCGATTGAGTGGCCGCAATAATCTCTACAAAATCA
AATTATGTTCTTCTGGCTATCGTTTAGTCTACGAAGTCAATGATCATGCTATTGTTTTACTGGTGATCGCTGTTGGTAAA
AGATCTGGAAATCAGGTTTATTCAGTCGCTGATGAACGTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT233774 WP_000212724.1 NZ_CP091563:489499-489741 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT233774 NZ_LN681227:c2939773-2939522 [Xenorhabdus nematophila AN6/1]
ATGTCTTATCAGATCCTGACAACAATAGCAGCCAGCATTACCGATTTGAAACGCAATCCCATGGGAACCGTCGCTGATGG
TGAAGGTGGTGCTGTCGCTATCCTGAACCGTAATGAACCTGCATTCTATTGTGTTCCACCCGAGCTTTACGCTTACTATT
TAGAACTTGCAGAGGATGCAGAATTAAATCACATCGCAGATGAACGGATGAAATCCGCTGAATTTGTGAGCGTCGATCTC
AATGACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References