Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4429980..4430761 Replicon chromosome
Accession NZ_CP091560
Organism Salmonella enterica strain 179

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag INN78_RS21790 Protein ID WP_000626099.1
Coordinates 4429980..4430471 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag INN78_RS21795 Protein ID WP_001110452.1
Coordinates 4430468..4430761 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN78_RS21750 (4425166) 4425166..4425408 - 243 WP_197603740.1 hypothetical protein -
INN78_RS21755 (4425405) 4425405..4425761 - 357 WP_033567083.1 hypothetical protein -
INN78_RS21760 (4425758) 4425758..4426630 - 873 WP_033567082.1 ParA family protein -
INN78_RS21765 (4426821) 4426821..4426898 - 78 Protein_4264 helix-turn-helix domain-containing protein -
INN78_RS21770 (4426989) 4426989..4427321 - 333 WP_001165471.1 MerR family transcriptional regulator -
INN78_RS21775 (4427393) 4427393..4427770 + 378 WP_000916345.1 EthD family reductase -
INN78_RS21780 (4428803) 4428803..4428877 + 75 Protein_4267 porin family protein -
INN78_RS21785 (4428980) 4428980..4429732 + 753 WP_000842434.1 non-specific acid phosphatase -
INN78_RS21790 (4429980) 4429980..4430471 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
INN78_RS21795 (4430468) 4430468..4430761 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
INN78_RS21800 (4431078) 4431078..4431299 + 222 WP_001576552.1 hypothetical protein -
INN78_RS21805 (4431564) 4431564..4432439 + 876 WP_000921674.1 AraC family transcriptional regulator -
INN78_RS21810 (4432436) 4432436..4432723 + 288 WP_001269916.1 transcriptional regulator RtsB -
INN78_RS21815 (4432746) 4432746..4432961 + 216 WP_001595136.1 hypothetical protein -
INN78_RS21820 (4432969) 4432969..4433238 + 270 WP_010989096.1 hypothetical protein -
INN78_RS21825 (4433532) 4433532..4434437 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T233769 WP_000626099.1 NZ_CP091560:c4430471-4429980 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T233769 NZ_LN681227:c1844732-1844559 [Xenorhabdus nematophila AN6/1]
ATGATATTTAATATCGAGTTTGACGAACGCGCGGTAAAAGAATGGCAAAAGCTGGATAACAGCATTCGTGAACAGTTTAA
AAAGAAGCTGAAAAAGTTACAGAAAAACCCTTATATCGAGCCTGCCAGACTACATGGCGATTTAGCGTGTTTTCTGAGGA
ATTTTTCTTTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT233769 WP_001110452.1 NZ_CP091560:c4430761-4430468 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT233769 NZ_LN681227:c1844976-1844722 [Xenorhabdus nematophila AN6/1]
ATGAGCACCATCCAAATAAGAGTAGATGAAGAGCTTAAGAAAAGTGCATATCAGGCATTTGATAAGCTGAATCTGTCCCC
TTCTGATGCAATGCGACTCTTCCTGCGTTATGTGGCAGAACATGAAAAGCTACCATTTACTGAGGTATCGGTGATGGTTG
CAGAGCACGATGAAGATGAAGATATTCTGGATGTAGTACGCGATCGCCTAAAGAATCCTGCCAAACGAATCCGGGTAAAT
CTCGATGATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References