Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4219902..4220418 Replicon chromosome
Accession NZ_CP091560
Organism Salmonella enterica strain 179

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag INN78_RS20685 Protein ID WP_000220578.1
Coordinates 4219902..4220186 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag INN78_RS20690 Protein ID WP_000212724.1
Coordinates 4220176..4220418 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN78_RS20670 (4215114) 4215114..4216766 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
INN78_RS20675 (4217175) 4217175..4219313 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
INN78_RS20680 (4219434) 4219434..4219898 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
INN78_RS20685 (4219902) 4219902..4220186 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INN78_RS20690 (4220176) 4220176..4220418 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
INN78_RS20695 (4220496) 4220496..4222409 - 1914 WP_001212137.1 BglG family transcription antiterminator -
INN78_RS20700 (4222426) 4222426..4223166 - 741 WP_000779263.1 KDGP aldolase family protein -
INN78_RS20705 (4223163) 4223163..4224281 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
INN78_RS20710 (4224265) 4224265..4225398 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T233768 WP_000220578.1 NZ_CP091560:c4220186-4219902 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T233768 NZ_LN681227:834993-835196 [Xenorhabdus nematophila AN6/1]
ATGACTAAAACTGACTATCTGATGCGTTTGAGAAAATGCACTTCTATTGAAACACTGGAACGTGTAATTGAAAAAAATAA
ATATGAACTTTCGGATGATGAACTTGAATTGTTCTACTCCGCTGCTGACCACCGTTTAGCCGAACTTACCATGAATAAAC
TCTATGATAAAATCCCATCATCTGTTTGGAAATTCGTCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT233768 WP_000212724.1 NZ_CP091560:c4220418-4220176 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT233768 NZ_LN681227:834578-834946 [Xenorhabdus nematophila AN6/1]
ATGGATGAATATTCACCAAAAAGATATGATATCGCTGAATTAAAATACTTGTGTGAAAAATTAATTCATGAGGCACTTTC
AGTCCTGAATCGCGCTGATAGTCACTGGATTCACGATCTGACTTCCGAGAAAAGCTTAAAATTAAACGAATTGATCGAAC
ACATTGCAGCTTTTGTCTGGAACTTTAAAATTAAATACACTGATCACTACGATCTCAGCACCTTAATTGATGAGTATCTG
GATGAAACATATAATTTGTTTGGAAGCGATAAGATAAGCTTTCTTGAACTTACTAAATGGCAAAGAACAAACGAACACTT
AACTAACATTCTGCTACATGATTTGAATGCTTCTTTAAGTAAAACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References