Detailed information of TA system TA233767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 4125641..4126217
• Replicon: chromosome
• Accession: NZ_CP091560
• Organism: Salmonella enterica strain 179

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: M7RG88
• Locus tag: INN78_RS20290
• Protein ID: WP_001131963.1
• Coordinates: 4125930..4126217 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: B5R9R5
• Locus tag: INN78_RS20285
• Protein ID: WP_000063142.1
• Coordinates: 4125641..4125943 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN78_RS20270 (4122151)	4122151..4124301	+	2151	WP_000379927.1	pyruvate/proton symporter BtsT	-
INN78_RS20275 (4124396)	4124396..4124599	+	204	WP_000460616.1	YbdD/YjiX family protein	-
INN78_RS20280 (4124610)	4124610..4125566	+	957	WP_000187839.1	GTPase	-
INN78_RS20285 (4125641)	4125641..4125943	-	303	WP_000063142.1	BrnA antitoxin family protein	Antitoxin
INN78_RS20290 (4125930)	4125930..4126217	-	288	WP_001131963.1	BrnT family toxin	Toxin
INN78_RS20295 (4126486)	4126486..4127400	-	915	WP_000290512.1	restriction endonuclease	-
INN78_RS20300 (4127598)	4127598..4131107	+	3510	WP_001043484.1	type I restriction-modification system endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (37-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11294.80 Da
• Isoelectric Point: 9.5894

>T233767 WP_001131963.1 NZ_CP091560:c4126217-4125930 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Nucleotide

• Length: 288 bp

>T233767 NZ_LN681227:c489707-489513 [Xenorhabdus nematophila AN6/1]
ATAGACTACATATCTATAGATTGTAGTCTATATACTCGAACAATCCGGGCATTTTTTGCATTTGATCCAGAACGTCAGGC
TGTTGTTTTTTGCGCAGGAAATAAAGCAGGGAAAAACCAAAAGTCATTCTATCGGGATATGATTAAGGTTGCTGACGAAC
AATTCAGAATCCATCTAAACAATTTGGAGAAATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11373.96 Da
• Isoelectric Point: 10.1293

>AT233767 WP_000063142.1 NZ_CP091560:c4125943-4125641 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Nucleotide

• Length: 303 bp

>AT233767 NZ_LN681227:c489511-489212 [Xenorhabdus nematophila AN6/1]
ATGGCTACTTTAAAAGAACTGATGGCAAAACGTAGCCCAGAAAGTCAAGCCAAAATAGAAGAAAAAGCAGCCGAAATGTT
GCTTGAAACGCAACTATACCAAATTCGTGAAGCATTAGCCCTTTCACAAACTCAGGTAGCAAAAAACCTGGGTATAGCCC
AATCATCAGTTGCAGCTATTGAACAACGAGGAAATGAATTGAAAATTTCCACACTGAAAAAATACATTGAAGCGATGGGC
GGCGAAATGACTTTGGGAGTCAAATTACCTGATGGAAAATTAATGAATTTCTCCATTTAA

Structures

Toxin

• PDB: 7VD7

Antitoxin

• AlphaFold DB: A0A4D6PB01