Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4125641..4126217 Replicon chromosome
Accession NZ_CP091560
Organism Salmonella enterica strain 179

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag INN78_RS20290 Protein ID WP_001131963.1
Coordinates 4125930..4126217 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag INN78_RS20285 Protein ID WP_000063142.1
Coordinates 4125641..4125943 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN78_RS20270 (4122151) 4122151..4124301 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
INN78_RS20275 (4124396) 4124396..4124599 + 204 WP_000460616.1 YbdD/YjiX family protein -
INN78_RS20280 (4124610) 4124610..4125566 + 957 WP_000187839.1 GTPase -
INN78_RS20285 (4125641) 4125641..4125943 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
INN78_RS20290 (4125930) 4125930..4126217 - 288 WP_001131963.1 BrnT family toxin Toxin
INN78_RS20295 (4126486) 4126486..4127400 - 915 WP_000290512.1 restriction endonuclease -
INN78_RS20300 (4127598) 4127598..4131107 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T233767 WP_001131963.1 NZ_CP091560:c4126217-4125930 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T233767 NZ_LN681227:c489707-489513 [Xenorhabdus nematophila AN6/1]
ATAGACTACATATCTATAGATTGTAGTCTATATACTCGAACAATCCGGGCATTTTTTGCATTTGATCCAGAACGTCAGGC
TGTTGTTTTTTGCGCAGGAAATAAAGCAGGGAAAAACCAAAAGTCATTCTATCGGGATATGATTAAGGTTGCTGACGAAC
AATTCAGAATCCATCTAAACAATTTGGAGAAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT233767 WP_000063142.1 NZ_CP091560:c4125943-4125641 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT233767 NZ_LN681227:c489511-489212 [Xenorhabdus nematophila AN6/1]
ATGGCTACTTTAAAAGAACTGATGGCAAAACGTAGCCCAGAAAGTCAAGCCAAAATAGAAGAAAAAGCAGCCGAAATGTT
GCTTGAAACGCAACTATACCAAATTCGTGAAGCATTAGCCCTTTCACAAACTCAGGTAGCAAAAAACCTGGGTATAGCCC
AATCATCAGTTGCAGCTATTGAACAACGAGGAAATGAATTGAAAATTTCCACACTGAAAAAATACATTGAAGCGATGGGC
GGCGAAATGACTTTGGGAGTCAAATTACCTGATGGAAAATTAATGAATTTCTCCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References