Detailed information of TA system TA233763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3505390..3506010
• Replicon: chromosome
• Accession: NZ_CP091560
• Organism: Salmonella enterica strain 179

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: INN78_RS17405
• Protein ID: WP_001280991.1
• Coordinates: 3505792..3506010 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: INN78_RS17400
• Protein ID: WP_000344807.1
• Coordinates: 3505390..3505764 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN78_RS17390 (3500529)	3500529..3501722	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
INN78_RS17395 (3501745)	3501745..3504894	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
INN78_RS17400 (3505390)	3505390..3505764	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
INN78_RS17405 (3505792)	3505792..3506010	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
INN78_RS17410 (3506189)	3506189..3506740	+	552	WP_001278792.1	maltose O-acetyltransferase	-
INN78_RS17415 (3506857)	3506857..3507327	+	471	WP_000136181.1	YlaC family protein	-
INN78_RS17420 (3507383)	3507383..3507523	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
INN78_RS17425 (3507529)	3507529..3507789	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
INN78_RS17430 (3508014)	3508014..3509564	+	1551	WP_000213139.1	EAL domain-containing protein	-
INN78_RS17440 (3509795)	3509795..3510184	+	390	WP_000961285.1	MGMT family protein	-
INN78_RS17445 (3510217)	3510217..3510786	-	570	WP_000779803.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	allD / allC / allB / allR / allA / allS / acrA / acrB	3434693..3682737	248044

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T233763 WP_001280991.1 NZ_CP091560:3505792-3506010 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T233763 NZ_LN681227:100846-101154 [Xenorhabdus nematophila AN6/1]
GTGTATAAGAGACAGGTATTCAGTAGGGAACGGGCAGAGTTGTTAACCGACGATGAATTTAGACACTTACAGGAACATTT
ACTAAAGAATCATGAACAAGGCAGTACCATTAGTGCTACTGGAGGATGCAAAAAGATTCGCTTGCAGCGGGAAGGAATGG
GAAAACGTGGCGGTGTCAGAATTATCTACTACACCATCATTAAAACCGGAATGCTCTATCTTCTTTTGATTTACCCTAAA
AATAAAAAAGATGACTTAACCCCAAAACAAAAAGAAGTACTTAAAGCCATCAGTAATAAATTGCAATAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT233763 WP_000344807.1 NZ_CP091560:3505390-3505764 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT233763 NZ_LN681227:101200-101496 [Xenorhabdus nematophila AN6/1]
ATGGACAAAAAACTTTTTGATGATTTGATTGAAAGCATGAATCAAATGGTAGCGATTGATAAAGGGGAACTTTCTGTTCC
TGCTGAAAATATTCATCGTCATCGTCTGCCTGATGTAAAAAAACTACGCGAAACCTTTGGGTTAAAGCAAAGTGAATTTG
CCGAAGCTGTTGGCGTTTCTGCATCCTTGATCCAAAGCTGGGAGCAACACCGCCGTACTCCTTCTGGTTCATCACTTAAA
TTGCTTAAAATGCTTGAACGTAATCCTGCGCTGATTAATGAATTAAGCGCGCTTTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0