Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84083..85706 Replicon plasmid p418-mcr
Accession NZ_CP091559
Organism Salmonella enterica strain 418

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag INN79_RS25130 Protein ID WP_140780865.1
Coordinates 84381..85706 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag INN79_RS25125 Protein ID WP_024136327.1
Coordinates 84083..84376 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN79_RS25100 (INN79_25095) 79955..81196 + 1242 WP_140780866.1 VWA domain-containing protein -
INN79_RS26290 81287..81418 + 132 WP_000374059.1 hypothetical protein -
INN79_RS25105 (INN79_25100) 81759..82040 - 282 WP_000077926.1 hypothetical protein -
INN79_RS25110 (INN79_25105) 82090..82281 - 192 WP_000398480.1 hypothetical protein -
INN79_RS25115 (INN79_25110) 82373..82714 - 342 WP_001151575.1 hypothetical protein -
INN79_RS25120 (INN79_25115) 83048..83479 + 432 WP_011152969.1 hypothetical protein -
INN79_RS25125 (INN79_25120) 84083..84376 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
INN79_RS25130 (INN79_25125) 84381..85706 + 1326 WP_140780865.1 type II toxin-antitoxin system HipA family toxin Toxin
INN79_RS25135 (INN79_25130) 85767..85973 + 207 WP_000134171.1 hypothetical protein -
INN79_RS25140 (INN79_25135) 86075..86458 + 384 WP_140780864.1 hypothetical protein -
INN79_RS25145 (INN79_25140) 86498..87313 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
INN79_RS25150 (INN79_25145) 87567..87992 + 426 WP_001043843.1 hypothetical protein -
INN79_RS25155 (INN79_25150) 88446..88682 + 237 Protein_86 type I restriction-modification system subunit M N-terminal domain-containing protein -
INN79_RS25160 (INN79_25155) 88737..89036 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / dfrA12 / aph(3')-Ia / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / blaCTX-M-14 / mcr-1.1 / qnrS2 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR - 1..287681 287681


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-108)

Antitoxin

(21-69)


Sequences


Toxin        


Download         Length: 442 a.a.        Molecular weight: 50291.28 Da        Isoelectric Point: 6.1927

>T233747 WP_140780865.1 NZ_CP091559:84381-85706 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHVEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T233747 NZ_LN649259:c2237970-2237794 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT233747 WP_024136327.1 NZ_CP091559:84083-84376 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT233747 NZ_LN649259:2237753-2237853 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References