Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 84083..85706 | Replicon | plasmid p418-mcr |
Accession | NZ_CP091559 | ||
Organism | Salmonella enterica strain 418 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | INN79_RS25130 | Protein ID | WP_140780865.1 |
Coordinates | 84381..85706 (+) | Length | 442 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
Locus tag | INN79_RS25125 | Protein ID | WP_024136327.1 |
Coordinates | 84083..84376 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
INN79_RS25100 (INN79_25095) | 79955..81196 | + | 1242 | WP_140780866.1 | VWA domain-containing protein | - |
INN79_RS26290 | 81287..81418 | + | 132 | WP_000374059.1 | hypothetical protein | - |
INN79_RS25105 (INN79_25100) | 81759..82040 | - | 282 | WP_000077926.1 | hypothetical protein | - |
INN79_RS25110 (INN79_25105) | 82090..82281 | - | 192 | WP_000398480.1 | hypothetical protein | - |
INN79_RS25115 (INN79_25110) | 82373..82714 | - | 342 | WP_001151575.1 | hypothetical protein | - |
INN79_RS25120 (INN79_25115) | 83048..83479 | + | 432 | WP_011152969.1 | hypothetical protein | - |
INN79_RS25125 (INN79_25120) | 84083..84376 | + | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
INN79_RS25130 (INN79_25125) | 84381..85706 | + | 1326 | WP_140780865.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
INN79_RS25135 (INN79_25130) | 85767..85973 | + | 207 | WP_000134171.1 | hypothetical protein | - |
INN79_RS25140 (INN79_25135) | 86075..86458 | + | 384 | WP_140780864.1 | hypothetical protein | - |
INN79_RS25145 (INN79_25140) | 86498..87313 | + | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
INN79_RS25150 (INN79_25145) | 87567..87992 | + | 426 | WP_001043843.1 | hypothetical protein | - |
INN79_RS25155 (INN79_25150) | 88446..88682 | + | 237 | Protein_86 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
INN79_RS25160 (INN79_25155) | 88737..89036 | + | 300 | WP_001572440.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | sul1 / dfrA12 / aph(3')-Ia / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / blaCTX-M-14 / mcr-1.1 / qnrS2 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR | - | 1..287681 | 287681 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50291.28 Da Isoelectric Point: 6.1927
>T233747 WP_140780865.1 NZ_CP091559:84381-85706 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHVEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHVEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
>T233747 NZ_LN649259:c2237970-2237794 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT233747 WP_024136327.1 NZ_CP091559:84083-84376 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
>AT233747 NZ_LN649259:2237753-2237853 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|