Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4570273..4571033 Replicon chromosome
Accession NZ_CP091558
Organism Salmonella enterica strain 418

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag INN79_RS22600 Protein ID WP_000533909.1
Coordinates 4570273..4570758 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag INN79_RS22605 Protein ID WP_000965886.1
Coordinates 4570746..4571033 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN79_RS22570 (4565343) 4565343..4566005 + 663 WP_000747548.1 OmpA family lipoprotein -
INN79_RS22575 (4566224) 4566224..4567198 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
INN79_RS22580 (4567248) 4567248..4567958 - 711 WP_000190524.1 DUF3053 domain-containing protein -
INN79_RS22585 (4568397) 4568397..4568687 + 291 WP_000455790.1 HTH-type transcriptional regulator -
INN79_RS22590 (4568976) 4568976..4569188 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
INN79_RS22595 (4569362) 4569362..4569901 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
INN79_RS22600 (4570273) 4570273..4570758 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
INN79_RS22605 (4570746) 4570746..4571033 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
INN79_RS22610 (4571211) 4571211..4571678 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
INN79_RS22615 (4571850) 4571850..4572125 - 276 Protein_4421 IS3 family transposase -
INN79_RS22620 (4572307) 4572307..4574376 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
INN79_RS22625 (4574386) 4574386..4575297 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
INN79_RS22630 (4575436) 4575436..4575738 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T233744 WP_000533909.1 NZ_CP091558:c4570758-4570273 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T233744 NZ_LN649259:c1349332-1348586 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATTCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATATGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT233744 WP_000965886.1 NZ_CP091558:c4571033-4570746 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT233744 NZ_LN649259:c1348586-1348416 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References