Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3710977..3711637 Replicon chromosome
Accession NZ_CP091558
Organism Salmonella enterica strain 418

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag INN79_RS18405 Protein ID WP_000244756.1
Coordinates 3711224..3711637 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag INN79_RS18400 Protein ID WP_000351186.1
Coordinates 3710977..3711243 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN79_RS18380 (3706905) 3706905..3708338 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
INN79_RS18385 (3708497) 3708497..3708808 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
INN79_RS18390 (3708972) 3708972..3709631 + 660 WP_000250289.1 hemolysin III family protein -
INN79_RS18395 (3709747) 3709747..3710727 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
INN79_RS18400 (3710977) 3710977..3711243 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
INN79_RS18405 (3711224) 3711224..3711637 + 414 WP_000244756.1 protein YgfX Toxin
INN79_RS18410 (3711690) 3711690..3712211 - 522 WP_001055885.1 flavodoxin FldB -
INN79_RS18415 (3712324) 3712324..3713220 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
INN79_RS18420 (3713244) 3713244..3713957 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
INN79_RS18425 (3713963) 3713963..3715696 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T233739 WP_000244756.1 NZ_CP091558:3711224-3711637 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T233739 NZ_LN626917:c2182279-2182070 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT233739 WP_000351186.1 NZ_CP091558:3710977-3711243 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233739 NZ_LN626917:c2182584-2182291 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References