233730

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2289549..2290071 Replicon chromosome
Accession NZ_CP091558
Organism Salmonella enterica strain 418

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag INN79_RS11295 Protein ID WP_000221343.1
Coordinates 2289549..2289833 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag INN79_RS11300 Protein ID WP_000885424.1
Coordinates 2289823..2290071 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN79_RS11275 (2285624) 2285624..2287132 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
INN79_RS11280 (2287177) 2287177..2287665 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
INN79_RS11285 (2287858) 2287858..2288937 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
INN79_RS11290 (2288989) 2288989..2289378 - 390 WP_000194089.1 RidA family protein -
INN79_RS11295 (2289549) 2289549..2289833 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INN79_RS11300 (2289823) 2289823..2290071 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
INN79_RS11305 (2290223) 2290223..2290438 + 216 WP_000206207.1 hypothetical protein -
INN79_RS11310 (2290428) 2290428..2290760 + 333 WP_000253154.1 DUF1493 family protein -
INN79_RS11315 (2290903) 2290903..2291811 + 909 WP_010989018.1 hypothetical protein -
INN79_RS11320 (2291867) 2291867..2292581 - 715 Protein_2208 helix-turn-helix domain-containing protein -
INN79_RS11325 (2293389) 2293389..2294855 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T233730 WP_000221343.1 NZ_CP091558:c2289833-2289549 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T233730 NZ_LN626917:c376663-376559 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGATTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT233730 WP_000885424.1 NZ_CP091558:c2290071-2289823 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT233730 NZ_LN626917:376466-376504 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References