Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1241554..1242174 Replicon chromosome
Accession NZ_CP091558
Organism Salmonella enterica strain 418

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag INN79_RS06030 Protein ID WP_001280991.1
Coordinates 1241554..1241772 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag INN79_RS06035 Protein ID WP_000344807.1
Coordinates 1241800..1242174 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN79_RS05990 (1236778) 1236778..1237347 + 570 WP_000779803.1 YbaY family lipoprotein -
INN79_RS05995 (1237380) 1237380..1237769 - 390 WP_000961285.1 MGMT family protein -
INN79_RS06005 (1238000) 1238000..1239550 - 1551 WP_000213139.1 EAL domain-containing protein -
INN79_RS06010 (1239775) 1239775..1240035 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
INN79_RS06015 (1240041) 1240041..1240181 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
INN79_RS06020 (1240237) 1240237..1240707 - 471 WP_000136181.1 YlaC family protein -
INN79_RS06025 (1240824) 1240824..1241375 - 552 WP_001278792.1 maltose O-acetyltransferase -
INN79_RS06030 (1241554) 1241554..1241772 - 219 WP_001280991.1 HHA domain-containing protein Toxin
INN79_RS06035 (1241800) 1241800..1242174 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
INN79_RS06040 (1242670) 1242670..1245819 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
INN79_RS06045 (1245842) 1245842..1247035 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T233729 WP_001280991.1 NZ_CP091558:c1241772-1241554 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233729 NZ_LN614828:c140788-140492 [Legionella fallonii LLAP-10]
ATGCCAAATAAAACATATCGTCTTTATCCAAAGGCTATAGAGGATCTTGAGTCAATCTATTTATATAGTATGCGAGAATT
TGGGATCAAAAGGACAGAAGATTATATTTTGACAATTGAAACAAGCTTCCAGTATCTTGCAGACGATCCACTTATTTCTC
GAACATGTGATTATGTCCGTCAGGATTTGAGGGCTTTCAATGTAGGTTCTCATGTTATTTTTTTCAAAATGACTCATTAT
GGTATTGCAGTTATTCGGGTGTTGCATCAATCTATGGATTTTAATAGACACTTTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT233729 WP_000344807.1 NZ_CP091558:c1242174-1241800 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT233729 NZ_LN614828:c141032-140778 [Legionella fallonii LLAP-10]
ATGGCTCGCACAATGACAGTGGATTTGGGCAGTGAACTTCGTGATTATGTTCAGTTTCTTGTGGATTCAGGAGATTATAG
AAGTAATAGCGAAGTATTAAGAGAATCATTACGTCTTCTTCGTGAAAAACAAGCTGAATCAAAGCTTGAGCAGTTGCGTC
ATCTTATCGATGAAGGGGAGGGCAGCGGCGATCCATTAATGTGGAACGCGGAAGAATTTCTTGATCGCATGAAGAAAGTC
CCTCATGCCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References