Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 359897..360678 Replicon chromosome
Accession NZ_CP091558
Organism Salmonella enterica strain 418

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag INN79_RS01780 Protein ID WP_000626099.1
Coordinates 360187..360678 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag INN79_RS01775 Protein ID WP_001110452.1
Coordinates 359897..360190 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN79_RS01745 (356221) 356221..357126 + 906 WP_001268200.1 YjiK family protein -
INN79_RS01750 (357420) 357420..357689 - 270 WP_010989096.1 hypothetical protein -
INN79_RS01755 (357697) 357697..357912 - 216 WP_001595136.1 hypothetical protein -
INN79_RS01760 (357935) 357935..358222 - 288 WP_001269916.1 transcriptional regulator RtsB -
INN79_RS01765 (358219) 358219..359094 - 876 WP_000921674.1 AraC family transcriptional regulator -
INN79_RS01770 (359359) 359359..359580 - 222 WP_001576552.1 hypothetical protein -
INN79_RS01775 (359897) 359897..360190 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
INN79_RS01780 (360187) 360187..360678 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
INN79_RS01785 (360926) 360926..361678 - 753 WP_000842434.1 non-specific acid phosphatase -
INN79_RS01790 (361781) 361781..361855 - 75 Protein_344 porin family protein -
INN79_RS01795 (362888) 362888..363265 - 378 WP_000916345.1 EthD family reductase -
INN79_RS01800 (363337) 363337..363669 + 333 WP_001165471.1 MerR family transcriptional regulator -
INN79_RS01805 (363760) 363760..363837 + 78 Protein_347 helix-turn-helix domain-containing protein -
INN79_RS01815 (364108) 364108..364683 - 576 WP_001188509.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T233723 WP_000626099.1 NZ_CP091558:360187-360678 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T233723 NZ_LN614756:c2865651-2865493 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT233723 WP_001110452.1 NZ_CP091558:359897-360190 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT233723 NZ_LN614756:2865442-2865576 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References