Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4351559..4352340 Replicon chromosome
Accession NZ_CP091556
Organism Salmonella enterica strain 632

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag INN80_RS21465 Protein ID WP_000626099.1
Coordinates 4351559..4352050 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag INN80_RS21470 Protein ID WP_001110452.1
Coordinates 4352047..4352340 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN80_RS21425 (4346745) 4346745..4346987 - 243 WP_197603740.1 hypothetical protein -
INN80_RS21430 (4346984) 4346984..4347340 - 357 WP_033567083.1 hypothetical protein -
INN80_RS21435 (4347337) 4347337..4348209 - 873 WP_033567082.1 ParA family protein -
INN80_RS21440 (4348400) 4348400..4348477 - 78 Protein_4200 helix-turn-helix domain-containing protein -
INN80_RS21445 (4348568) 4348568..4348900 - 333 WP_001165471.1 MerR family transcriptional regulator -
INN80_RS21450 (4348972) 4348972..4349349 + 378 WP_000916345.1 EthD family reductase -
INN80_RS21455 (4350382) 4350382..4350456 + 75 Protein_4203 porin family protein -
INN80_RS21460 (4350559) 4350559..4351311 + 753 WP_000842434.1 non-specific acid phosphatase -
INN80_RS21465 (4351559) 4351559..4352050 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
INN80_RS21470 (4352047) 4352047..4352340 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
INN80_RS21475 (4352657) 4352657..4352878 + 222 WP_001576552.1 hypothetical protein -
INN80_RS21480 (4353143) 4353143..4354018 + 876 WP_000921674.1 AraC family transcriptional regulator -
INN80_RS21485 (4354015) 4354015..4354302 + 288 WP_001269916.1 transcriptional regulator RtsB -
INN80_RS21490 (4354325) 4354325..4354540 + 216 WP_001595136.1 hypothetical protein -
INN80_RS21495 (4354548) 4354548..4354817 + 270 WP_010989096.1 hypothetical protein -
INN80_RS21500 (4355111) 4355111..4356016 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T233719 WP_000626099.1 NZ_CP091556:c4352050-4351559 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T233719 NZ_LN614756:1129404-1129565 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT233719 WP_001110452.1 NZ_CP091556:c4352340-4352047 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT233719 NZ_LN614756:c1129618-1129485 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References