Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4141481..4141997 Replicon chromosome
Accession NZ_CP091556
Organism Salmonella enterica strain 632

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag INN80_RS20360 Protein ID WP_000220578.1
Coordinates 4141481..4141765 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag INN80_RS20365 Protein ID WP_000212724.1
Coordinates 4141755..4141997 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN80_RS20345 (4136693) 4136693..4138345 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
INN80_RS20350 (4138754) 4138754..4140892 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
INN80_RS20355 (4141013) 4141013..4141477 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
INN80_RS20360 (4141481) 4141481..4141765 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INN80_RS20365 (4141755) 4141755..4141997 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
INN80_RS20370 (4142075) 4142075..4143988 - 1914 WP_001212137.1 BglG family transcription antiterminator -
INN80_RS20375 (4144005) 4144005..4144745 - 741 WP_000779263.1 KDGP aldolase family protein -
INN80_RS20380 (4144742) 4144742..4145860 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
INN80_RS20385 (4145844) 4145844..4146977 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T233718 WP_000220578.1 NZ_CP091556:c4141765-4141481 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T233718 NZ_LN606600:2336499-2336909 [Acetobacter senegalensis]
GTGAGCGCCTATCTCCTTGATACCAATATCATCAGTGATCTTGTCCGAAATCCTTCCGGCCCGTGCGCGCGTCGCATCGA
ACGTATCGATCCCGGCGACCTTTGTACCAGCATTATTGTGGCCGCTGAGTTACGATATGGATGTGCTAAAAAAGGCTCTG
CAAAGCTGTTAAACCGGGTTGAAAGCGTGCTGGCGTTTGTCCCCGTGCTGCCTCTCGATATTCCTGCCGACTGTGAATAC
GGTGGCATCCGCGCCGAACTCGAAGCCGCAGGGCAGACGATCGGCATGAATGATCTGCTCATCGCGGCTCACGCCTACAC
CCTCAAGGCGACCCTGGTGACGAACAACACACGTGAGTTTATGCGCATTCGAGGCTTGAAGGTTGAAAACTGGCTGGAGG
ATGGGACGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT233718 WP_000212724.1 NZ_CP091556:c4141997-4141755 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT233718 NZ_LN606600:2336230-2336502 [Acetobacter senegalensis]
ATGCCAGTTCCTGAAGTGACTCCCCGACCGCGCGAAGTGAAACTCTTTCGGAACAATCGCAGTCAGGCTGTGCGTATTCC
AGTCGAATTTGAAATGCCAGGAGATCGCGTGCTGATACGCCGTGACGGTGACAAGCTCGTTCTGGAGCCTGTGAAAACCC
CTTCCACTCTGAAGGAGCTTCTCATGGCATGGCGCGAAGAACCGCAGCTGGCCCCCGAAGACGATTTTCCCGATATTCAG
GACGTAGCCGCCAGACCGGAAGATATTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References