Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4047220..4047796 Replicon chromosome
Accession NZ_CP091556
Organism Salmonella enterica strain 632

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag INN80_RS19965 Protein ID WP_001131963.1
Coordinates 4047509..4047796 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag INN80_RS19960 Protein ID WP_000063142.1
Coordinates 4047220..4047522 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN80_RS19945 (4043730) 4043730..4045880 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
INN80_RS19950 (4045975) 4045975..4046178 + 204 WP_000460616.1 YbdD/YjiX family protein -
INN80_RS19955 (4046189) 4046189..4047145 + 957 WP_000187839.1 GTPase -
INN80_RS19960 (4047220) 4047220..4047522 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
INN80_RS19965 (4047509) 4047509..4047796 - 288 WP_001131963.1 BrnT family toxin Toxin
INN80_RS19970 (4048065) 4048065..4048979 - 915 WP_000290512.1 restriction endonuclease -
INN80_RS19975 (4049177) 4049177..4052686 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T233717 WP_001131963.1 NZ_CP091556:c4047796-4047509 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T233717 NZ_LN606600:c1755292-1755029 [Acetobacter senegalensis]
ATGAGATACGATTGGGACGAAACAAAGCGCCAGAGCAACATCGCCAAACACGGCGTTGATTTTGTTGCCGCTGACGGCTT
TGAATGGGACGTTGCTTTTGTCATGACCAGCCAGAGCGCAAACGAACCACGCCTTGTCGCTATCGCTCCGATCAATCTGC
GCCTTCATGTGTTGGTTTTCAGCATTGAAACGCGCATTGTCCGCATCATCAGCCTGCGCAAGGCCAACAAACGGGAGGCA
AAGCTCTATGCCGCGCAAACCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT233717 WP_000063142.1 NZ_CP091556:c4047522-4047220 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT233717 NZ_LN606600:c1755021-1754737 [Acetobacter senegalensis]
ATGCCGACAGACGAGGAAGATGCCCGCATCAATCAGGGTATTGCTCTGGACGCAGACAACCCGGAACTGACCGAGCGGGA
TTTCCGGCGGGCGGTTCCTGCTTCCGTTATTGTGCCTGACCTTGCTTCTCAGCGACGAGTGCGGGGCCCACAGAAAGCCC
CGACGAAGACACTAGTCTCTATGCGTCTTGACCCGGATCTTCTTGAACGCTTGAAGGCGGATGGCCCCGGCTGGCAGTCC
CGTGCAAACGATATACTCCGGGAGGCTGTTGGTTTGTCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References