Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3426969..3427589 Replicon chromosome
Accession NZ_CP091556
Organism Salmonella enterica strain 632

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag INN80_RS17080 Protein ID WP_001280991.1
Coordinates 3427371..3427589 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag INN80_RS17075 Protein ID WP_000344807.1
Coordinates 3426969..3427343 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN80_RS17065 (3422108) 3422108..3423301 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
INN80_RS17070 (3423324) 3423324..3426473 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
INN80_RS17075 (3426969) 3426969..3427343 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
INN80_RS17080 (3427371) 3427371..3427589 + 219 WP_001280991.1 HHA domain-containing protein Toxin
INN80_RS17085 (3427768) 3427768..3428319 + 552 WP_001278792.1 maltose O-acetyltransferase -
INN80_RS17090 (3428436) 3428436..3428906 + 471 WP_000136181.1 YlaC family protein -
INN80_RS17095 (3428962) 3428962..3429102 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
INN80_RS17100 (3429108) 3429108..3429368 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
INN80_RS17105 (3429593) 3429593..3431143 + 1551 WP_000213139.1 EAL domain-containing protein -
INN80_RS17115 (3431374) 3431374..3431763 + 390 WP_000961285.1 MGMT family protein -
INN80_RS17120 (3431796) 3431796..3432365 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - allD / allC / allB / allR / allA / allS / acrA / acrB 3356272..3604316 248044


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T233713 WP_001280991.1 NZ_CP091556:3427371-3427589 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233713 NZ_LM995446:c4523808-4523467 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT233713 WP_000344807.1 NZ_CP091556:3426969-3427343 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT233713 NZ_LM995446:4523803-4523879 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References