Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 873406..874066 Replicon chromosome
Accession NZ_CP091556
Organism Salmonella enterica strain 632

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag INN80_RS04250 Protein ID WP_000244756.1
Coordinates 873653..874066 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag INN80_RS04245 Protein ID WP_000351186.1
Coordinates 873406..873672 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN80_RS04225 (869334) 869334..870767 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
INN80_RS04230 (870926) 870926..871237 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
INN80_RS04235 (871401) 871401..872060 + 660 WP_000250289.1 hemolysin III family protein -
INN80_RS04240 (872176) 872176..873156 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
INN80_RS04245 (873406) 873406..873672 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
INN80_RS04250 (873653) 873653..874066 + 414 WP_000244756.1 protein YgfX Toxin
INN80_RS04255 (874119) 874119..874640 - 522 WP_001055885.1 flavodoxin FldB -
INN80_RS04260 (874753) 874753..875649 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
INN80_RS04265 (875673) 875673..876386 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
INN80_RS04270 (876392) 876392..878125 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T233701 WP_000244756.1 NZ_CP091556:873653-874066 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T233701 NZ_LM995446:c2037768-2037517 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT233701 WP_000351186.1 NZ_CP091556:873406-873672 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233701 NZ_LM995446:c2037520-2037266 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References