233694

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4537625..4538385 Replicon chromosome
Accession NZ_CP091554
Organism Salmonella enterica strain 751

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag INN81_RS22240 Protein ID WP_000533909.1
Coordinates 4537625..4538110 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag INN81_RS22245 Protein ID WP_000965886.1
Coordinates 4538098..4538385 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN81_RS22210 (4532695) 4532695..4533357 + 663 WP_000747548.1 OmpA family lipoprotein -
INN81_RS22215 (4533576) 4533576..4534550 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
INN81_RS22220 (4534600) 4534600..4535310 - 711 WP_000190524.1 DUF3053 domain-containing protein -
INN81_RS22225 (4535749) 4535749..4536039 + 291 WP_000455790.1 HTH-type transcriptional regulator -
INN81_RS22230 (4536328) 4536328..4536540 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
INN81_RS22235 (4536714) 4536714..4537253 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
INN81_RS22240 (4537625) 4537625..4538110 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
INN81_RS22245 (4538098) 4538098..4538385 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
INN81_RS22250 (4538563) 4538563..4539030 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
INN81_RS22255 (4539202) 4539202..4539477 - 276 Protein_4350 IS3 family transposase -
INN81_RS22260 (4539659) 4539659..4541728 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
INN81_RS22265 (4541738) 4541738..4542649 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
INN81_RS22270 (4542788) 4542788..4543090 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T233694 WP_000533909.1 NZ_CP091554:c4538110-4537625 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T233694 NZ_LM995446:c1362824-1362630 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT233694 WP_000965886.1 NZ_CP091554:c4538385-4538098 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT233694 NZ_LM995446:1362453-1362631 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References