233693

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4427822..4428408 Replicon chromosome
Accession NZ_CP091554
Organism Salmonella enterica strain 751

Toxin (Protein)


Gene name doc Uniprot ID E8XF70
Locus tag INN81_RS21760 Protein ID WP_001521773.1
Coordinates 4427822..4428190 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID M7SDJ3
Locus tag INN81_RS21765 Protein ID WP_001520924.1
Coordinates 4428187..4428408 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN81_RS21740 (4423382) 4423382..4424452 - 1071 WP_000907838.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
INN81_RS21745 (4424454) 4424454..4425299 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
INN81_RS21750 (4425296) 4425296..4426183 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
INN81_RS21755 (4426247) 4426247..4427563 - 1317 WP_000624747.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
INN81_RS21760 (4427822) 4427822..4428190 - 369 WP_001521773.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
INN81_RS21765 (4428187) 4428187..4428408 - 222 WP_001520924.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
INN81_RS21770 (4428540) 4428540..4429253 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
INN81_RS21775 (4429255) 4429255..4430022 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
INN81_RS21780 (4430019) 4430019..4431296 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
INN81_RS21785 (4431293) 4431293..4432219 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
INN81_RS21790 (4432279) 4432279..4433388 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4422645..4438629 15984


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13587.92 Da        Isoelectric Point: 7.3190

>T233693 WP_001521773.1 NZ_CP091554:c4428190-4427822 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Download         Length: 369 bp

>T233693 NZ_LM995446:c1220440-1220333 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8152.14 Da        Isoelectric Point: 5.0775

>AT233693 WP_001520924.1 NZ_CP091554:c4428408-4428187 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT233693 NZ_LM995446:1220487-1220553 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A607IPC3

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z871

References