233691

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3793408..3794068 Replicon chromosome
Accession NZ_CP091554
Organism Salmonella enterica strain 751

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag INN81_RS18555 Protein ID WP_000244756.1
Coordinates 3793408..3793821 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag INN81_RS18560 Protein ID WP_000351186.1
Coordinates 3793802..3794068 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN81_RS18535 (3789349) 3789349..3791082 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
INN81_RS18540 (3791088) 3791088..3791801 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
INN81_RS18545 (3791825) 3791825..3792721 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
INN81_RS18550 (3792834) 3792834..3793355 + 522 WP_001055885.1 flavodoxin FldB -
INN81_RS18555 (3793408) 3793408..3793821 - 414 WP_000244756.1 protein YgfX Toxin
INN81_RS18560 (3793802) 3793802..3794068 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
INN81_RS18565 (3794318) 3794318..3795298 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
INN81_RS18570 (3795414) 3795414..3796073 - 660 WP_000250289.1 hemolysin III family protein -
INN81_RS18575 (3796237) 3796237..3796548 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
INN81_RS18580 (3796707) 3796707..3798140 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T233691 WP_000244756.1 NZ_CP091554:c3793821-3793408 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T233691 NZ_LM995446:c1219370-1219263 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT233691 WP_000351186.1 NZ_CP091554:c3794068-3793802 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233691 NZ_LM995446:1219418-1219484 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References