233689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3634293..3635107 Replicon chromosome
Accession NZ_CP091554
Organism Salmonella enterica strain 751

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag INN81_RS17825 Protein ID WP_000971655.1
Coordinates 3634580..3635107 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag INN81_RS17820 Protein ID WP_000855692.1
Coordinates 3634293..3634583 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN81_RS17790 (3630243) 3630243..3630893 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
INN81_RS17795 (3631350) 3631350..3631793 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
INN81_RS17800 (3632224) 3632224..3632673 + 450 WP_000381610.1 membrane protein -
INN81_RS17805 (3632658) 3632658..3633005 + 348 WP_001669174.1 DUF1493 family protein -
INN81_RS17810 (3633278) 3633278..3633604 - 327 WP_000393302.1 hypothetical protein -
INN81_RS17815 (3633845) 3633845..3634023 + 179 Protein_3475 IS3 family transposase -
INN81_RS17820 (3634293) 3634293..3634583 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
INN81_RS17825 (3634580) 3634580..3635107 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
INN81_RS17830 (3635180) 3635180..3635385 - 206 Protein_3478 IS5/IS1182 family transposase -
INN81_RS17835 (3635732) 3635732..3636280 + 549 Protein_3479 protein-serine/threonine phosphatase -
INN81_RS17845 (3637614) 3637614..3637724 + 111 Protein_3481 serine/threonine protein phosphatase -
INN81_RS17850 (3637896) 3637896..3638417 - 522 WP_000858988.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T233689 WP_000971655.1 NZ_CP091554:3634580-3635107 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T233689 NZ_LM995446:c262893-262552 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT233689 WP_000855692.1 NZ_CP091554:3634293-3634583 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT233689 NZ_LM995446:c263231-262914 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A625WHV3

References