Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2213532..2214054 Replicon chromosome
Accession NZ_CP091554
Organism Salmonella enterica strain 751

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag INN81_RS10710 Protein ID WP_000221343.1
Coordinates 2213532..2213816 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag INN81_RS10715 Protein ID WP_000885424.1
Coordinates 2213806..2214054 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN81_RS10690 (2209607) 2209607..2211115 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
INN81_RS10695 (2211160) 2211160..2211648 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
INN81_RS10700 (2211841) 2211841..2212920 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
INN81_RS10705 (2212972) 2212972..2213361 - 390 WP_000194089.1 RidA family protein -
INN81_RS10710 (2213532) 2213532..2213816 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INN81_RS10715 (2213806) 2213806..2214054 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
INN81_RS10720 (2214206) 2214206..2214421 + 216 WP_000206207.1 hypothetical protein -
INN81_RS10725 (2214411) 2214411..2214743 + 333 WP_000253154.1 DUF1493 family protein -
INN81_RS10730 (2214886) 2214886..2215794 + 909 WP_010989018.1 hypothetical protein -
INN81_RS10735 (2215850) 2215850..2216564 - 715 Protein_2090 helix-turn-helix domain-containing protein -
INN81_RS10740 (2217372) 2217372..2218838 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T233680 WP_000221343.1 NZ_CP091554:c2213816-2213532 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T233680 NZ_CP091554:c2213816-2213532 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT233680 WP_000885424.1 NZ_CP091554:c2214054-2213806 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT233680 NZ_CP091554:c2214054-2213806 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References