Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1163210..1163830 Replicon chromosome
Accession NZ_CP091554
Organism Salmonella enterica strain 751

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag INN81_RS05425 Protein ID WP_001280991.1
Coordinates 1163210..1163428 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag INN81_RS05430 Protein ID WP_000344807.1
Coordinates 1163456..1163830 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN81_RS05385 (1158434) 1158434..1159003 + 570 WP_000779803.1 YbaY family lipoprotein -
INN81_RS05390 (1159036) 1159036..1159425 - 390 WP_000961285.1 MGMT family protein -
INN81_RS05400 (1159656) 1159656..1161206 - 1551 WP_000213139.1 EAL domain-containing protein -
INN81_RS05405 (1161431) 1161431..1161691 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
INN81_RS05410 (1161697) 1161697..1161837 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
INN81_RS05415 (1161893) 1161893..1162363 - 471 WP_000136181.1 YlaC family protein -
INN81_RS05420 (1162480) 1162480..1163031 - 552 WP_001278792.1 maltose O-acetyltransferase -
INN81_RS05425 (1163210) 1163210..1163428 - 219 WP_001280991.1 HHA domain-containing protein Toxin
INN81_RS05430 (1163456) 1163456..1163830 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
INN81_RS05435 (1164326) 1164326..1167475 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
INN81_RS05440 (1167498) 1167498..1168691 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - acrB / acrA / allS / allA / allR / allB / allC / allD 986747..1235599 248852


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T233679 WP_001280991.1 NZ_CP091554:c1163428-1163210 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T233679 NZ_LM993812:c2993203-2992796 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT233679 WP_000344807.1 NZ_CP091554:c1163830-1163456 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT233679 NZ_LM993812:c2993450-2993184 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References