Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 317320..318101 Replicon chromosome
Accession NZ_CP091554
Organism Salmonella enterica strain 751

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag INN81_RS01450 Protein ID WP_000626099.1
Coordinates 317610..318101 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag INN81_RS01445 Protein ID WP_001110452.1
Coordinates 317320..317613 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INN81_RS01415 (313644) 313644..314549 + 906 WP_001268200.1 YjiK family protein -
INN81_RS01420 (314843) 314843..315112 - 270 WP_010989096.1 hypothetical protein -
INN81_RS01425 (315120) 315120..315335 - 216 WP_001595136.1 hypothetical protein -
INN81_RS01430 (315358) 315358..315645 - 288 WP_001269916.1 transcriptional regulator RtsB -
INN81_RS01435 (315642) 315642..316517 - 876 WP_000921674.1 AraC family transcriptional regulator -
INN81_RS01440 (316782) 316782..317003 - 222 WP_001576552.1 hypothetical protein -
INN81_RS01445 (317320) 317320..317613 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
INN81_RS01450 (317610) 317610..318101 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
INN81_RS01455 (318349) 318349..319101 - 753 WP_000842434.1 non-specific acid phosphatase -
INN81_RS01460 (319204) 319204..319278 - 75 Protein_278 porin family protein -
INN81_RS01465 (320311) 320311..320688 - 378 WP_000916345.1 EthD family reductase -
INN81_RS01470 (320760) 320760..321092 + 333 WP_001165471.1 MerR family transcriptional regulator -
INN81_RS01475 (321183) 321183..321260 + 78 Protein_281 helix-turn-helix domain-containing protein -
INN81_RS01485 (321531) 321531..322106 - 576 WP_001188509.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T233673 WP_000626099.1 NZ_CP091554:317610-318101 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T233673 NZ_LM993812:2029176-2029550 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT233673 WP_001110452.1 NZ_CP091554:317320-317613 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT233673 NZ_LM993812:2028719-2029087 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References