Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4584671..4585431 Replicon chromosome
Accession NZ_CP091547
Organism Salmonella enterica strain 1559

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag L4413_RS22655 Protein ID WP_000533909.1
Coordinates 4584671..4585156 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag L4413_RS22660 Protein ID WP_000965886.1
Coordinates 4585144..4585431 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4413_RS22625 (4579741) 4579741..4580403 + 663 WP_000747548.1 OmpA family lipoprotein -
L4413_RS22630 (4580622) 4580622..4581596 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
L4413_RS22635 (4581646) 4581646..4582356 - 711 WP_000190524.1 DUF3053 domain-containing protein -
L4413_RS22640 (4582795) 4582795..4583085 + 291 WP_000455790.1 HTH-type transcriptional regulator -
L4413_RS22645 (4583374) 4583374..4583586 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
L4413_RS22650 (4583760) 4583760..4584299 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
L4413_RS22655 (4584671) 4584671..4585156 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
L4413_RS22660 (4585144) 4585144..4585431 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
L4413_RS22665 (4585609) 4585609..4586076 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
L4413_RS22670 (4586248) 4586248..4586523 - 276 Protein_4432 IS3 family transposase -
L4413_RS22675 (4586705) 4586705..4588774 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
L4413_RS22680 (4588784) 4588784..4589695 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
L4413_RS22685 (4589834) 4589834..4590136 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T233669 WP_000533909.1 NZ_CP091547:c4585156-4584671 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T233669 NZ_LM993812:1479246-1479422 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT233669 WP_000965886.1 NZ_CP091547:c4585431-4585144 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT233669 NZ_LM993812:1479468-1479884 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References