Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3872229..3872889 Replicon chromosome
Accession NZ_CP091547
Organism Salmonella enterica strain 1559

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag L4413_RS19160 Protein ID WP_000244756.1
Coordinates 3872229..3872642 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag L4413_RS19165 Protein ID WP_000351186.1
Coordinates 3872623..3872889 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4413_RS19140 (3868170) 3868170..3869903 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
L4413_RS19145 (3869909) 3869909..3870622 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L4413_RS19150 (3870646) 3870646..3871542 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
L4413_RS19155 (3871655) 3871655..3872176 + 522 WP_001055885.1 flavodoxin FldB -
L4413_RS19160 (3872229) 3872229..3872642 - 414 WP_000244756.1 protein YgfX Toxin
L4413_RS19165 (3872623) 3872623..3872889 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
L4413_RS19170 (3873139) 3873139..3874119 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
L4413_RS19175 (3874235) 3874235..3874894 - 660 WP_000250289.1 hemolysin III family protein -
L4413_RS19180 (3875058) 3875058..3875369 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
L4413_RS19185 (3875528) 3875528..3876961 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T233666 WP_000244756.1 NZ_CP091547:c3872642-3872229 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T233666 NZ_LM993812:c1254992-1254885 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT233666 WP_000351186.1 NZ_CP091547:c3872889-3872623 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233666 NZ_LM993812:1255040-1255106 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References