Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 3872229..3872889 | Replicon | chromosome |
Accession | NZ_CP091547 | ||
Organism | Salmonella enterica strain 1559 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | Q57K70 |
Locus tag | L4413_RS19160 | Protein ID | WP_000244756.1 |
Coordinates | 3872229..3872642 (-) | Length | 138 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | S5MU13 |
Locus tag | L4413_RS19165 | Protein ID | WP_000351186.1 |
Coordinates | 3872623..3872889 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L4413_RS19140 (3868170) | 3868170..3869903 | - | 1734 | WP_000813394.1 | single-stranded-DNA-specific exonuclease RecJ | - |
L4413_RS19145 (3869909) | 3869909..3870622 | - | 714 | WP_000745625.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
L4413_RS19150 (3870646) | 3870646..3871542 | - | 897 | WP_000434302.1 | site-specific tyrosine recombinase XerD | - |
L4413_RS19155 (3871655) | 3871655..3872176 | + | 522 | WP_001055885.1 | flavodoxin FldB | - |
L4413_RS19160 (3872229) | 3872229..3872642 | - | 414 | WP_000244756.1 | protein YgfX | Toxin |
L4413_RS19165 (3872623) | 3872623..3872889 | - | 267 | WP_000351186.1 | FAD assembly factor SdhE | Antitoxin |
L4413_RS19170 (3873139) | 3873139..3874119 | + | 981 | WP_000874172.1 | tRNA-modifying protein YgfZ | - |
L4413_RS19175 (3874235) | 3874235..3874894 | - | 660 | WP_000250289.1 | hemolysin III family protein | - |
L4413_RS19180 (3875058) | 3875058..3875369 | - | 312 | WP_001182976.1 | N(4)-acetylcytidine aminohydrolase | - |
L4413_RS19185 (3875528) | 3875528..3876961 | + | 1434 | WP_001230141.1 | 6-phospho-beta-glucosidase BglA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 16183.15 Da Isoelectric Point: 10.7537
>T233666 WP_000244756.1 NZ_CP091547:c3872642-3872229 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH
Download Length: 414 bp
>T233666 NZ_LM993812:c1254992-1254885 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10550.05 Da Isoelectric Point: 6.0783
>AT233666 WP_000351186.1 NZ_CP091547:c3872889-3872623 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT233666 NZ_LM993812:1255040-1255106 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3Z1E9V5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5I0YWH4 |