233655

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2291071..2291593 Replicon chromosome
Accession NZ_CP091547
Organism Salmonella enterica strain 1559

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag L4413_RS11310 Protein ID WP_000221343.1
Coordinates 2291071..2291355 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag L4413_RS11315 Protein ID WP_000885424.1
Coordinates 2291345..2291593 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4413_RS11290 (2287146) 2287146..2288654 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
L4413_RS11295 (2288699) 2288699..2289187 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
L4413_RS11300 (2289380) 2289380..2290459 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
L4413_RS11305 (2290511) 2290511..2290900 - 390 WP_000194089.1 RidA family protein -
L4413_RS11310 (2291071) 2291071..2291355 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L4413_RS11315 (2291345) 2291345..2291593 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L4413_RS11320 (2291745) 2291745..2291960 + 216 WP_000206207.1 hypothetical protein -
L4413_RS11325 (2291950) 2291950..2292282 + 333 WP_000253154.1 DUF1493 family protein -
L4413_RS11330 (2292425) 2292425..2293333 + 909 WP_010989018.1 hypothetical protein -
L4413_RS11335 (2293389) 2293389..2294103 - 715 Protein_2210 helix-turn-helix domain-containing protein -
L4413_RS11340 (2294911) 2294911..2296377 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T233655 WP_000221343.1 NZ_CP091547:c2291355-2291071 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T233655 NZ_LK021129:576592-576870 [Vibrio anguillarum]
ATGATTTTATGGGAAGAGGAATCGCTAAATGATCGTGAGAAGATCTTTGAGTTTCTTTATGACTTTAACCCTGATGCGGC
TGAAAAAACTGATGACATTATTGAGGCTAAAGTAGAAAACTTACTCGAACAACCATTGATGGGTGTTCAACGGGATGGAA
TTCGAGGACGATTACTCATTATTCCCGAAATCTCAATGATCGTTTCGTACTGGGTAGAAGGTTCAATTATTCGCATAATG
CGAGTTCTACACCAGAAGCAGAAATTCCCTACCGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT233655 WP_000885424.1 NZ_CP091547:c2291593-2291345 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT233655 NZ_LK021129:576311-576595 [Vibrio anguillarum]
ATGGACACTCGAATTCAATTTCGTGTTGATGACGAAATTAAACGTTTAGCCCAACAAATGGCTGAGAGCCAAGGTCGCAC
ACTCAGCGATGCTTGCCGTGAACTTACTGAACAAATGGCTGAGCAACAAAGAAAAACATTATCTCATGACGCTTGGTTAA
CTGAACAAATAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTTCATTTGTTGAACATAATTCAGCTAAAGCACGA
ATGGCTGAACGAAAGGCCAAAATTCGTAATCGAGGCCAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References