Detailed information of TA system TA233654

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1241556..1242176
• Replicon: chromosome
• Accession: NZ_CP091547
• Organism: Salmonella enterica strain 1559

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: L4413_RS06030
• Protein ID: WP_001280991.1
• Coordinates: 1241556..1241774 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: L4413_RS06035
• Protein ID: WP_000344807.1
• Coordinates: 1241802..1242176 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L4413_RS05990 (1236780)	1236780..1237349	+	570	WP_000779803.1	YbaY family lipoprotein	-
L4413_RS05995 (1237382)	1237382..1237771	-	390	WP_000961285.1	MGMT family protein	-
L4413_RS06005 (1238002)	1238002..1239552	-	1551	WP_000213139.1	EAL domain-containing protein	-
L4413_RS06010 (1239777)	1239777..1240037	+	261	WP_000801415.1	type B 50S ribosomal protein L31	-
L4413_RS06015 (1240043)	1240043..1240183	+	141	WP_001197749.1	type B 50S ribosomal protein L36	-
L4413_RS06020 (1240239)	1240239..1240709	-	471	WP_000136181.1	YlaC family protein	-
L4413_RS06025 (1240826)	1240826..1241377	-	552	WP_001278792.1	maltose O-acetyltransferase	-
L4413_RS06030 (1241556)	1241556..1241774	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
L4413_RS06035 (1241802)	1241802..1242176	-	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
L4413_RS06040 (1242672)	1242672..1245821	-	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
L4413_RS06045 (1245844)	1245844..1247037	-	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T233654 WP_001280991.1 NZ_CP091547:c1241774-1241556 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T233654 NZ_LK021129:c550263-549730 [Vibrio anguillarum]
GTGAGTTGGGGCAGAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGGTCAAC
CGCTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGACA
CAGTTAGCAAAGAAACTACCGAGATATCCAATCCCTGTTTTTCTGTTGGCTCAATTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATTCGTGCGCTGAAGTACTTGTGGGAAGTAAATCATCACATGAGGGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTACTTACCGATGAAAACGGTAGAACAGCTTTTTAATCAATAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT233654 WP_000344807.1 NZ_CP091547:c1242176-1241802 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT233654 NZ_LK021129:c550691-550260 [Vibrio anguillarum]
GTGTTTACAGTGTGTTTTTTGAGTTCGGCGGTGCGTTGTCAACCCCTTAGCCGGGCGTTATATTCTCCCTCGTTCCGTAA
ACTTTCCGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTATGCAGGAGGGG
TTATGGCAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGC
TTAAAAAGTCTCACTGAATACGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTAT
GGTTAAAGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTG
TTAAATTTACAGAGAAGAGCGGTATCAAGTGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0