233649

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 489499..490015 Replicon chromosome
Accession NZ_CP091547
Organism Salmonella enterica strain 1559

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag L4413_RS02455 Protein ID WP_000220578.1
Coordinates 489731..490015 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L4413_RS02450 Protein ID WP_000212724.1
Coordinates 489499..489741 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4413_RS02430 (484519) 484519..485652 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
L4413_RS02435 (485636) 485636..486754 + 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L4413_RS02440 (486751) 486751..487491 + 741 WP_000779263.1 KDGP aldolase family protein -
L4413_RS02445 (487508) 487508..489421 + 1914 WP_001212137.1 BglG family transcription antiterminator -
L4413_RS02450 (489499) 489499..489741 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L4413_RS02455 (489731) 489731..490015 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L4413_RS02460 (490019) 490019..490483 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L4413_RS02465 (490604) 490604..492742 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
L4413_RS02470 (493151) 493151..494803 - 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T233649 WP_000220578.1 NZ_CP091547:489731-490015 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T233649 NZ_LC127084:2628417-2629073 [Edwardsiella tarda]
GTGGCCTACGACTACAGCGCCAACCTCAACCCGGAAAAAGCCCTGATTTGGCGCATTGTCCATCGGGATAATATCCCGTG
GATACTGGACCACGGTCTGCACTGCGGCAACAGCCCGGTGCAGGCGGCAAACTGGATCAATATCGGCAACCCGGAACTTA
TCGGCAAACGCGCCGGGCATCCGGTGCCTGTCGGTATGGGCGGGACGCTGCATGACTACGTGCCGTTTTACTTTACCCCC
TTTTCGCCGATGCTGATGAATATCCACAGCGGGCGTGGCGGCATTACGCAGCGCCCCAATGAGGAAATCGTCATTCTGGT
CAGCAACCTGCGAAACGTGGCGGCGCAGAACATCCCCTTCGTGTTTACCGACAGCCACGCCTACTATAACTGGGTCAACT
ACTACACCCGTCTGGACGATCTGAACCAGATCGACTGGTCTATCTTACAGGCGCGGGATTTCCGTCGCGATCCAGACGAT
CCGGCGAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGCAGCACTGCCCCATCACACTGCTGGTCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGCTGTCGCAACGTAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT233649 WP_000212724.1 NZ_CP091547:489499-489741 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT233649 NZ_LC127084:2629070-2630137 [Edwardsiella tarda]
ATGATCACATATACACAAGGCAATTTACTGGACGCGCCTGTGGAAGCACTGGTGAATACGGTGAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTTAAAGAGCGCTTCCCCGACAATATGAAAGCCTATGCCCACGCCTGCAAACAAAAGC
AGGTGATGACCGGCAAGATGTTTATTACCGAAACCGGCGAGCTGATGGGGCCACGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCCCGCATGGCGTGGATCGAAGACGGTTTGCAGGACTTGCGCCGCTTTTTGATCGAAAAGAA
AGTGCGGTCCATCGCCATTCCCCCGCTGGGCGCGGGCAACGGCGGCCTGAACTGGCCGGACGTCCGGGCGCGGATTGAAT
CTACGCTGGGCGACCTTCAGGACACGGAAATCCTGATTTATGAGCCTACCGAAAAATACCAGAATGTCGCCAAGAGCAGC
GGTGTAAAAAAGCTCACGCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGTATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGCTACAACGCGCCATTGAACAGCACCAGCAGGAGGACGTGTTAAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTATGCTCCTAACCTGAACCATCTGCTTAACGCGCTGGACGGTACCTATCTGAAA
GCCGAGAAACGTATCCCGGACAGCCAGCCACTGGATGTGATCTGGTTTAACGATCGGGAAAAAGAACACATCAACCTATG
GCTGAACAGCGAAGCCAAAGCGTGGTTGCCAGCGCTTGAGCAGGTCAGCCAGTTGATTGACGGTTTTGAATCGCCGTTTG
GTCTGGAGCTGTTGGCGACCGTTGACTGGTTGTTGACCCGGGGACAATGCCAGCCGACGCTGGACTCGGTGAAAGAGGGG
TTGCATCAGTGGCCTGCGGGAGAACCTTGGGCCAGCCGTAAGATAAAGCTGTTTGACGATAAGAATCTGCAATTCGCCAT
TAACCGCGTGATGGAGTTTCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References